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    NEL1 GTPase-activating protein NEL1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856430, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NEL1
    Official Full Name
    GTPase-activating protein NEL1
    Primary source
    SGD:S000001077
    Locus tag
    YHR035W
    See related
    AllianceGenome:SGD:S000001077; FungiDB:YHR035W; VEuPathDB:YHR035W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activator activity. Predicted to be involved in COPII-coated vesicle cargo loading. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NEL1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (178219..180111)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene putative glutamate 5-kinase Neighboring gene Pih1p Neighboring gene Brl1p Neighboring gene 1-pyrroline-5-carboxylate dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sec23 homolog Nel1 is a novel GTPase-activating protein for Sar1 but does not function as a subunit of the coat protein complex II (COPII) coat. Kodera C, et al. J Biol Chem, 2014 Aug 1. PMID 24947508, Free PMC Article
    2. ER exit sites are physical and functional core autophagosome biogenesis components. Graef M, et al. Mol Biol Cell, 2013 Sep. PMID 23904270, Free PMC Article
    3. Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens. Fromont-Racine M, et al. Nat Genet, 1997 Jul. PMID 9207794
    4. Genome-wide protein interaction screens reveal functional networks involving Sm-like proteins. Fromont-Racine M, et al. Yeast, 2000 Jun 30. PMID 10900456, Free PMC Article
    5. Comprehensive and quantitative mapping of RNA-protein interactions across a transcribed eukaryotic genome. She R, et al. Proc Natl Acad Sci U S A, 2017 Apr 4. PMID 28325876, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. demonstrated that the chromosomal deletion of NEL1 leads to a significant growth defect in the temperature-sensitive sar1D32G background, suggesting a possible functional link between these proteins
      Title: Sec23 homolog Nel1 is a novel GTPase-activating protein for Sar1 but does not function as a subunit of the coat protein complex II (COPII) coat.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPII vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GTPase-activating protein NEL1
    NP_011900.1
    • Activator of Sar1p GTPase activity; paralog of Sec23 but does not associate with the COPII components; not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      178219..180111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179165.1 → NP_011900.1  TPA: GTPase-activating protein NEL1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011900.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKY2, P38769
      UniProtKB/TrEMBL
      C7GTU5, G2WFA7, N1P397
      Conserved Domains (1) summary
      COG5047
      Location:1 → 630
      SEC23; Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38769.1

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