Sh3glb2 SH3 domain-containing GRB2-like endophilin B2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sh3glb2provided by RGD
Official Full Name: SH3 domain-containing GRB2-like endophilin B2provided by RGD
Primary source: RGD:1305886
See related: EnsemblRapid:ENSRNOG00000017295 AllianceGenome:RGD:1305886
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Involved in postsynaptic neurotransmitter receptor internalization. Is active in glutamatergic synapse and postsynaptic endocytic zone. Orthologous to human SH3GLB2 (SH3 domain containing GRB2 like, endophilin B2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 436.1), Adrenal (RPKM 142.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (34014746..34029607, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (13616936..13631785, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (8909231..8924066, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Through direct interactions with F-actin and EndoB2, CPG2 physically bridges the spine cytoskeleton and the endocytic machinery, and this tripartite association is critical specifically for activity-dependent clathrin-mediated endocytosis of synaptic glutamate receptors.
Title: CPG2 Recruits Endophilin B2 to the Cytoskeleton for Activity-Dependent Endocytosis of Synaptic Glutamate Receptors.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in membrane organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic neurotransmitter receptor internalization	IEP Inferred from Expression Pattern more info	PubMed
involved_in postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic endocytic zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic endocytic zone	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: endophilin-B2

Names: SH3 domain-containing GRB2-like protein B2; SH3-containing protein SH3GLB2; SH3-domain GRB2-like endophilin B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393780.1 → NP_001380709.1 endophilin-B2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A0G2K9P4

Conserved Domains (2) summary

cd07617
Location:21 → 278

BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2

cl17036
Location:335 → 361

SH3; Src Homology 3 domain superfamily
NM_001393781.1 → NP_001380710.1 endophilin-B2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A0G2K9P4, A6JTX4

Related

ENSRNOP00000077030.2, ENSRNOT00000103772.2

Conserved Domains (2) summary

cd07617
Location:21 → 278

BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2

cd11944
Location:339 → 393

SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

RNA

NR_172010.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

34014746..34029607 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008761662.4 → XP_008759884.1 endophilin-B2 isoform X5

See identical proteins and their annotated locations for XP_008759884.1

UniProtKB/TrEMBL

A0A8I6GHN4, A6JTX1, A6JTX3

Conserved Domains (2) summary

cd07617
Location:21 → 257

BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2

cd11944
Location:318 → 372

SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
XM_006233822.5 → XP_006233884.1 endophilin-B2 isoform X4

UniProtKB/TrEMBL

A6JTX1

Related

ENSRNOP00000089795.2, ENSRNOT00000107109.2

Conserved Domains (2) summary

cd07617
Location:21 → 257

BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2

cd11944
Location:323 → 377

SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
XM_006233819.5 → XP_006233881.1 endophilin-B2 isoform X3

UniProtKB/TrEMBL

A0A0G2K9P4

Conserved Domains (2) summary

cd07617
Location:21 → 278

BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2

cd11944
Location:344 → 398

SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
XM_063283947.1 → XP_063140017.1 endophilin-B2 isoform X2

UniProtKB/TrEMBL

A0A8I6GM93

Related

ENSRNOP00000084372.2, ENSRNOT00000116758.2
XM_008761661.4 → XP_008759883.1 endophilin-B2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZZ43, A0A8I6GM93

Related

ENSRNOP00000085000.2, ENSRNOT00000100859.2

Conserved Domains (2) summary

cd11944
Location:394 → 448

SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

cl12013
Location:21 → 328

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_063283948.1 → XP_063140018.1 endophilin-B2 isoform X6

UniProtKB/TrEMBL

A6JTX6
XM_039105239.2 → XP_038961167.1 endophilin-B2 isoform X8

Conserved Domains (1) summary

cd07617
Location:21 → 257

BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
XM_063283949.1 → XP_063140019.1 endophilin-B2 isoform X7
XM_063283950.1 → XP_063140020.1 endophilin-B2 isoform X9

UniProtKB/TrEMBL

A6JTX9