H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: H6pdprovided by RGD
Official Full Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)provided by RGD
Primary source: RGD:1306562
See related: EnsemblRapid:ENSRNOG00000017523 AllianceGenome:RGD:1306562
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: H6pdh
Summary: Enables NADP binding activity; carbohydrate binding activity; and glucose-6-phosphate dehydrogenase activity. Involved in NADP metabolic process; response to alcohol; and response to nutrient levels. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in cortisone reductase deficiency; cortisone reductase deficiency 1; and multiple sclerosis. Orthologous to human H6PD (hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 249.6), Kidney (RPKM 191.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (165717456..165753158, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (160434499..160470203, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (166994683..167030441, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results demonstrate the existence of a separate intraluminal pyridine nucleotide pool in the hepatic endoplasmic reticulum and a close cooperation between 11betaHSD1 and H6PDH based on their co-localization.
Title: Cooperativity between 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase is based on a common pyridine nucleotide pool in the lumen of the endoplasmic reticulum.
It was found that H6PD was present in all investigated tissues; both expression and activity remained within an order of magnitude. Correlation was found between the dehydrogenase activity and protein or mRNA levels.
Title: Expression of hexose-6-phosphate dehydrogenase in rat tissues.
Activation of expression and activity of Hexose-6-phosphate dehydrogenase in primary hepatocytes was mediated through levels of glucose, not related to insulin levels so concluding that glucose instead of insulin directly regulates H6PDH.
Title: Direct regulation of glucose and not insulin on hepatic hexose-6-phosphate dehydrogenase and 11β-hydroxysteroid dehydrogenase type 1.
H6PDH was amply expressed in most tissues examined in which 11beta-HSD1 was also expressed, with the notable exception of the renal interstitial cells
Title: Hexose-6-phosphate dehydrogenase and 11beta-hydroxysteroid dehydrogenase-1 tissue distribution in the rat.
This study showed that sucrose can promote increased 11Beta-hydroxysteroid dehydrogenase-1 (11beta-HSD-1) and Hexose-6-phosphate dehydrogenase (H6PDH) message in mesenteric fat while concomitantly decreasing the enzyme messages in liver.
Title: Sucrose access differentially modifies 11beta-hydroxysteroid dehydrogenase-1 and hexose-6-phosphate dehydrogenase message in liver and adipose tissue in rats.
adipocytes are equipped with a functional G6PT-hexose-6-phosphate dehydrogenase-11beta-hydroxysteroid dehydrogenase type 1 system
Title: The glucose-6-phosphate transporter-hexose-6-phosphate dehydrogenase-11beta-hydroxysteroid dehydrogenase type 1 system of the adipose tissue.

Submit: New GeneRIF Correction

General gene information

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Markers

AI785303 (e-PCR)
- UniSTS:179105

NoName (e-PCR)
- UniSTS:546813

H6pd (e-PCR), detects polymorphism
- UniSTS:546813

RH140648 (e-PCR)
- UniSTS:222717

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 6-phosphogluconolactonase activity	ISO Inferred from Sequence Orthology more info
enables NADP binding	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	IDA Inferred from Direct Assay more info	PubMed
enables glucose-6-phosphate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucose-6-phosphate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose-6-phosphate dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NADP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pentose-phosphate shunt	ISO Inferred from Sequence Orthology more info
involved_in pentose-phosphate shunt, oxidative branch	IBA Inferred from Biological aspect of Ancestor more info
involved_in pentose-phosphate shunt, oxidative branch	ISO Inferred from Sequence Orthology more info
involved_in regulation of cortisol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to alcohol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	ISO Inferred from Sequence Orthology more info
is_active_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GDH/6PGL endoplasmic bifunctional protein

NP_001100168.1

EC 1.1.1.363

EC 1.1.1.47

EC 3.1.1.31

XP_006239521.1

EC 1.1.1.363

EC 1.1.1.47

EC 3.1.1.31

XP_006239522.1

EC 1.1.1.363

EC 1.1.1.47

EC 3.1.1.31

XP_038965633.1

EC 1.1.1.363

EC 1.1.1.47

EC 3.1.1.31

XP_038965634.1

EC 1.1.1.363

EC 1.1.1.47

EC 3.1.1.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106698.1 → NP_001100168.1 GDH/6PGL endoplasmic bifunctional protein precursor

See identical proteins and their annotated locations for NP_001100168.1

Status: PROVISIONAL

Source sequence(s)

CH473968

UniProtKB/TrEMBL

A0A8I5ZNT3, A6IUC4, D4A7D7

Related

ENSRNOP00000023543.5, ENSRNOT00000023543.7

Conserved Domains (4) summary

COG0364
Location:27 → 510

Zwf; Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]

TIGR01198
Location:562 → 797

pgl; 6-phosphogluconolactonase

pfam00479
Location:34 → 216

G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain

pfam02781
Location:230 → 517

G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

165717456..165753158 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109705.2 → XP_038965633.1 GDH/6PGL endoplasmic bifunctional protein isoform X1

UniProtKB/TrEMBL

A0A8I5ZNT3, A0A8I6ANS1, A6IUC5

Conserved Domains (2) summary

PTZ00309
Location:23 → 502

PTZ00309; glucose-6-phosphate 1-dehydrogenase; Provisional

TIGR01198
Location:554 → 789

pgl; 6-phosphogluconolactonase
XM_006239460.5 → XP_006239522.1 GDH/6PGL endoplasmic bifunctional protein isoform X1

See identical proteins and their annotated locations for XP_006239522.1

UniProtKB/TrEMBL

A0A8I5ZNT3, A0A8I6ANS1, A6IUC5

Conserved Domains (2) summary

PTZ00309
Location:23 → 502

PTZ00309; glucose-6-phosphate 1-dehydrogenase; Provisional

TIGR01198
Location:554 → 789

pgl; 6-phosphogluconolactonase
XM_006239459.5 → XP_006239521.1 GDH/6PGL endoplasmic bifunctional protein isoform X1

See identical proteins and their annotated locations for XP_006239521.1

UniProtKB/TrEMBL

A0A8I5ZNT3, A0A8I6ANS1, A6IUC5

Conserved Domains (2) summary

PTZ00309
Location:23 → 502

PTZ00309; glucose-6-phosphate 1-dehydrogenase; Provisional

TIGR01198
Location:554 → 789

pgl; 6-phosphogluconolactonase
XM_039109706.2 → XP_038965634.1 GDH/6PGL endoplasmic bifunctional protein isoform X1

UniProtKB/TrEMBL

A0A8I5ZNT3, A0A8I6ANS1, A6IUC5

Conserved Domains (2) summary

PTZ00309
Location:23 → 502

PTZ00309; glucose-6-phosphate 1-dehydrogenase; Provisional

TIGR01198
Location:554 → 789

pgl; 6-phosphogluconolactonase