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    Sap130 Sin3A associated protein 130 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307527, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sap130provided by RGD
    Official Full Name
    Sin3A associated protein 130provided by RGD
    Primary source
    RGD:1311657
    See related
    EnsemblRapid:ENSRNOG00000016773 AllianceGenome:RGD:1311657
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311657
    Summary
    Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nuclear speck. Predicted to be part of Sin3-type complex. Orthologous to human SAP130 (Sin3A associated protein 130). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 45.8), Thymus (RPKM 44.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sap130 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (23518773..23619840)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (23244337..23345368)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (24397523..24497831)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35 like 1 Neighboring gene uncharacterized LOC134482923 Neighboring gene solute carrier family 25, member 46 Neighboring gene AMMECR1 like Neighboring gene uncharacterized LOC100910201 Neighboring gene RNA polymerase II subunit D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Icardi L, et al. Proc Natl Acad Sci U S A, 2012 Jul 24. PMID 22783022, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone deacetylase complex subunit SAP130
    NP_001414044.1
    XP_006254667.1
    XP_006254668.1
    XP_006254669.1
    XP_017456575.1
    XP_038953244.1
    XP_038953245.1
    XP_063133456.1
    XP_063133457.1
    XP_063133458.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427115.1 → NP_001414044.1  histone deacetylase complex subunit SAP130

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      D3ZLP9
      Related
      ENSRNOP00000022761.8, ENSRNOT00000022761.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      23518773..23619840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254605.4 → XP_006254667.1  histone deacetylase complex subunit SAP130 isoform X1

      See identical proteins and their annotated locations for XP_006254667.1

      UniProtKB/TrEMBL
      D3ZLP9
      Related
      ENSRNOP00000112150.1, ENSRNOT00000163641.1
      Conserved Domains (1) summary
      pfam16014
      Location:649 → 1054
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

    2. XM_006254606.5 → XP_006254668.1  histone deacetylase complex subunit SAP130 isoform X2

      See identical proteins and their annotated locations for XP_006254668.1

      Conserved Domains (1) summary
      pfam16014
      Location:648 → 1053
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

    3. XM_017601086.3 → XP_017456575.1  histone deacetylase complex subunit SAP130 isoform X5

    4. XM_039097317.2 → XP_038953245.1  histone deacetylase complex subunit SAP130 isoform X7

      Conserved Domains (2) summary
      PHA03247
      Location:7 → 352
      PHA03247; large tegument protein UL36; Provisional
      pfam05109
      Location:243 → 527
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    5. XM_063277386.1 → XP_063133456.1  histone deacetylase complex subunit SAP130 isoform X4

    6. XM_063277388.1 → XP_063133458.1  histone deacetylase complex subunit SAP130 isoform X6

    7. XM_063277387.1 → XP_063133457.1  histone deacetylase complex subunit SAP130 isoform X4

      Related
      ENSRNOP00000107068.1, ENSRNOT00000138732.1

    8. XM_039097316.2 → XP_038953244.1  histone deacetylase complex subunit SAP130 isoform X3

      UniProtKB/TrEMBL
      D3ZLP9
      Conserved Domains (2) summary
      PHA03247
      Location:55 → 493
      PHA03247; large tegument protein UL36; Provisional
      pfam16014
      Location:636 → 1041
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus

    9. XM_006254607.5 → XP_006254669.1  histone deacetylase complex subunit SAP130 isoform X3

      See identical proteins and their annotated locations for XP_006254669.1

      UniProtKB/TrEMBL
      D3ZLP9
      Conserved Domains (2) summary
      PHA03247
      Location:55 → 493
      PHA03247; large tegument protein UL36; Provisional
      pfam16014
      Location:636 → 1041
      SAP130_C; Histone deacetylase complex subunit SAP130 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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