Nxf1 nuclear RNA export factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nxf1provided by MGI
Official Full Name: nuclear RNA export factor 1provided by MGI
Primary source: MGI:MGI:1858330
See related: Ensembl:ENSMUSG00000010097 AllianceGenome:MGI:1858330
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tap; Mvb1; Mex67
Summary: Enables mRNA binding activity. Acts upstream of or within poly(A)+ mRNA export from nucleus. Located in nuclear inclusion body. Part of nuclear pore. Is expressed in several structures, including central nervous system; genitourinary system; liver; sensory organ; and spleen. Orthologous to human NXF1 (nuclear RNA export factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 63.9), bladder adult (RPKM 56.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.5 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (8734467..8748274)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (8757103..8770910)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Germline heterozygous mutations in Nxf1 perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice.
Title: Germline heterozygous mutations in Nxf1 perturb RNA metabolism and trigger thrombocytopenia and lymphopenia in mice.
NXF1 and CRM1 nuclear export pathways orchestrate nuclear export, translation and packaging of murine leukaemia retrovirus unspliced RNA.
Title: NXF1 and CRM1 nuclear export pathways orchestrate nuclear export, translation and packaging of murine leukaemia retrovirus unspliced RNA.
Mutation E610G, quantitatively accounts for the Nxf1 modifier gene activity toward IAP insertion.
Title: Nxf1 natural variant E610G is a semi-dominant suppressor of IAP-induced RNA processing defects.
Taken together, the results show for the first time that murine leukemia virus requires the Tap/NXF1-mediated export pathway for the expression of its spliced and unspliced RNAs and for full-legth RNA nuclear export.
Title: MLV requires Tap/NXF1-dependent pathway to export its unspliced RNA to the cytoplasm and to express both spliced and unspliced RNAs.
Disruption of NXF1 expression impaired cytoplasmic accumulations of both spliced and unspliced RNA transcripts of Murine leukemia virus.
Title: Murine leukemia virus uses NXF1 for nuclear export of spliced and unspliced viral transcripts.
Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases.
Title: Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases.
The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.
Title: The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.
Nxf1 suppresses a class of intracisternal A particle (IAP)-induced mutations, including Ap3d1(mh2J), a model for Hermansky-Pudlak syndrome, and Atcay(hes), a model for Cayman ataxia
Title: Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing.
CAST allele of Nxf1 suppresses IAP-Idelta1 insertions in Ap3d1[mh2J], Atcay[hes], Mgrn1[md] and Usp14[axJ]. Does not suppress the Mitf[mi-bw] LINE nor any of six tested ETn insertion alleles.
Title: Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing.
FMRP and Nxf2 associate with and destabilize Nxf1 mRNA in neuronal cells.
Title: Fragile X mental retardation protein FMRP and the RNA export factor NXF2 associate with and destabilize Nxf1 mRNA in neuronal cells.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Spontaneous (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127663 (e-PCR)
- UniSTS:210973

Nxf1 (e-PCR), detects polymorphism
- UniSTS:479014

AU014962 (e-PCR)
- UniSTS:167250

AV208457 (e-PCR)
- UniSTS:166124

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within poly(A)+ mRNA export from nucleus	IPI Inferred from Physical Interaction more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
part_of nuclear RNA export factor complex	IEA Inferred from Electronic Annotation more info
part_of nuclear RNA export factor complex	ISO Inferred from Sequence Orthology more info
located_in nuclear inclusion body	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription export complex	ISO Inferred from Sequence Orthology more info
part_of transcription export complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nuclear RNA export factor 1

Names: Mex 67 homolog; mRNA export factor TAP; modifier of vibrator 1; nuclear RNA export factor 1 homolog; tip associated protein; tip associating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276704.1 → NP_001263633.1 nuclear RNA export factor 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate internal segment and transcription extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK143640

Consensus CDS

CCDS70930.1

UniProtKB/TrEMBL

V9GXF3

Related

ENSMUSP00000139124.2, ENSMUST00000184970.9

Conserved Domains (4) summary

sd00035
Location:223 → 265

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:115 → 197

Tap-RNA_bind; Tap, RNA-binding

pfam12799
Location:290 → 328

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:264 → 326

LRR_8; Leucine rich repeat
NM_016813.2 → NP_058093.2 nuclear RNA export factor 1 isoform 1

See identical proteins and their annotated locations for NP_058093.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BC005594

Consensus CDS

CCDS29543.1

UniProtKB/Swiss-Prot

O88985, Q3TJA5, Q99JX7

UniProtKB/TrEMBL

Q8BP60

Related

ENSMUSP00000010241.7, ENSMUST00000010241.14

Conserved Domains (6) summary

smart00804
Location:555 → 617

TAP_C; C-terminal domain of vertebrate Tap protein

cd00780
Location:381 → 537

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

sd00035
Location:223 → 265

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:115 → 197

Tap-RNA_bind; Tap, RNA-binding

pfam12799
Location:290 → 328

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:264 → 326

LRR_8; Leucine rich repeat