Akap8l A kinase anchor protein 8-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akap8lprovided by MGI
Official Full Name: A kinase anchor protein 8-likeprovided by MGI
Primary source: MGI:MGI:1860606
See related: Ensembl:ENSMUSG00000002625 AllianceGenome:MGI:1860606
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HAP95; Nakap95
Summary: Predicted to enable histone deacetylase binding activity; lamin binding activity; and protein kinase A regulatory subunit binding activity. Predicted to be involved in several processes, including cell cycle G2/M phase transition; mitotic chromosome condensation; and regulation of mRNA export from nucleus. Located in nuclear matrix. Is expressed in several structures, including central nervous system and retina. Orthologous to human AKAP8L (A-kinase anchoring protein 8 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cortex adult (RPKM 62.0), frontal lobe adult (RPKM 58.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 17.5 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (32540398..32569589, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (32321424..32350616, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microglial AKAP8L: a key mediator in diabetes-associated cognitive impairment via autophagy inhibition and neuroinflammation triggering.
Title: Microglial AKAP8L: a key mediator in diabetes-associated cognitive impairment via autophagy inhibition and neuroinflammation triggering.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables lamin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell cycle G2/M phase transition	ISO Inferred from Sequence Orthology more info
involved_in mRNA processing	ISO Inferred from Sequence Orthology more info
involved_in mitotic chromosome condensation	ISO Inferred from Sequence Orthology more info
involved_in nuclear membrane disassembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nuclear matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: A-kinase anchor protein 8-like

Names: A kinase (PRKA) anchor protein 8-like; AKAP8-like protein; neighbor of A-kinase anchoring protein 95; neighbor of AKAP95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403535.1 → NP_001390464.1 A-kinase anchor protein 8-like isoform 2

Status: VALIDATED

Source sequence(s)

CT033751

UniProtKB/TrEMBL

A0A494B9L0

Related

ENSMUSP00000157684.2, ENSMUST00000236503.2
NM_001403536.1 → NP_001390465.1 A-kinase anchor protein 8-like isoform 3

Status: VALIDATED

Source sequence(s)

CT033751
NM_017476.3 → NP_059504.2 A-kinase anchor protein 8-like isoform 1

See identical proteins and their annotated locations for NP_059504.2

Status: VALIDATED

Source sequence(s)

CT033751

Consensus CDS

CCDS50058.1

UniProtKB/TrEMBL

Q5RL57, Q9D0K8

Related

ENSMUSP00000051389.8, ENSMUST00000050214.9

Conserved Domains (1) summary

pfam04988
Location:389 → 553

AKAP95; A-kinase anchoring protein 95 (AKAP95)

RNA

NR_175380.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT033751
NR_175381.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT033751
NR_175382.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT033751
NR_175383.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT033751
NR_175384.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT033751
NR_175385.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT033751
NR_175386.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT033751
NR_175387.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

CT033751

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

32540398..32569589 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030249905.2 → XP_030105765.1 A-kinase anchor protein 8-like isoform X3

Conserved Domains (1) summary

pfam04988
Location:389 → 512

AKAP95; A-kinase anchoring protein 95 (AKAP95)