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    KPNA2 karyopherin subunit alpha 2 [ Sus scrofa (pig) ]

    Gene ID: 397218, updated on 17-Aug-2024

    Summary

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    Official Symbol
    KPNA2provided by VGNC
    Official Full Name
    karyopherin subunit alpha 2provided by VGNC
    Primary source
    VGNC:VGNC:89561
    See related
    Ensembl:ENSSSCG00000029005
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Ubiquitous expression in ovary (RPKM 54.6), spleen (RPKM 41.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See KPNA2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 12 NC_010454.4 (14283092..14296749)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003540521.1 (23..1809, complement)

    Chromosome 12 - NC_010454.4Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene chromosome 12 C17orf58 homolog Neighboring gene transfer RNA arginine (anticodon CCG) Neighboring gene SMAD specific E3 ubiquitin protein ligase 2 Neighboring gene centrosomal protein 95

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. A crucial role of N-terminal domain of influenza A virus M1 protein in interaction with swine importin α1 protein. Liu Q, et al. Virus Genes, 2014 Aug. PMID 24743939, Free PMC Article
    2. Identification of karyopherin α1 and α7 interacting proteins in porcine tissue. Park KE, et al. PLoS One, 2012. PMID 22720010, Free PMC Article
    3. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Authors demonstrated that swine importin alpha1 interacts with the M1 protein and transports it to the nucleus.
      Title: A crucial role of N-terminal domain of influenza A virus M1 protein in interaction with swine importin α1 protein.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear localization sequence binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    importin subunit alpha-1
    Names
    karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163404.1 → NP_001156876.1  importin subunit alpha-1

      See identical proteins and their annotated locations for NP_001156876.1

      Status: PROVISIONAL

      Source sequence(s)
      GQ166956
      UniProtKB/TrEMBL
      A0A8D0P9S6, C6K7I0
      Related
      ENSSSCP00000043346.3, ENSSSCT00000040768.3
      Conserved Domains (5) summary
      COG5064
      Location:10 → 528
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:113 → 238
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:10 → 98
      IBB; Importin beta binding domain
      pfam16186
      Location:458 → 508
      Arm_3; Atypical Arm repeat
      sd00043
      Location:253 → 278
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010454.4 Reference Sscrofa11.1 Primary Assembly

      Range
      14283092..14296749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021066215.1 → XP_020921874.1  importin subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A4X1SWR0, A0A8D0P9S6, A0A8D0SF82, I3LS70
      Related
      ENSSSCP00000026961.2, ENSSSCT00000022690.4
      Conserved Domains (2) summary
      sd00043
      Location:253 → 278
      ARM; armadillo repeat [structural motif]
      cl25709
      Location:10 → 528
      Arm_3; Atypical Arm repeat
    Nucleotide Protein
    Heading Accession and Version

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