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    IFIT3 interferon induced protein with tetratricopeptide repeats 3 [ Sus scrofa (pig) ]

    Gene ID: 100154248, updated on 3-Dec-2024

    Summary

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    Official Symbol
    IFIT3provided by VGNC
    Official Full Name
    interferon induced protein with tetratricopeptide repeats 3provided by VGNC
    Primary source
    VGNC:VGNC:107401
    See related
    Ensembl:ENSSSCG00000061268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Ubiquitous expression in spleen (RPKM 74.1), lung (RPKM 68.4) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See IFIT3 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 14 NC_010456.5 (101214730..101225169)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 14 NC_010456.4 (110209344..110210870)

    Chromosome 14 - NC_010456.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102164066 Neighboring gene cholesterol 25-hydroxylase Neighboring gene lipase A, lysosomal acid type Neighboring gene interferon induced protein with tetratricopeptide repeats 2 Neighboring gene interferon-induced protein with tetratricopeptide repeats 1 Neighboring gene interferon induced protein with tetratricopeptide repeats 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Bat and pig IFN-induced transmembrane protein 3 restrict cell entry by influenza virus and lyssaviruses. Benfield CTO, et al. J Gen Virol, 2015 May. PMID 25614588, Free PMC Article
    2. Porcine interferon-induced protein with tetratricopeptide repeats 3, poIFIT3, inhibits swine influenza virus replication and potentiates IFN-β production. Li Y, et al. Dev Comp Immunol, 2015 May. PMID 25451299
    3. PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences. Uenishi H, et al. Nucleic Acids Res, 2007 Jan. PMID 17145712, Free PMC Article
    4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. poIFIT3 plays a significant role in the clearance of swine influenza virus in pigs and potentiates IFN-beta production.
      Title: Porcine interferon-induced protein with tetratricopeptide repeats 3, poIFIT3, inhibits swine influenza virus replication and potentiates IFN-β production.
    2. Authors showed that IFITM3 functions as potent broad-spectrum antiviral effector in two mammals - pigs and bats.
      Title: Bat and pig IFN-induced transmembrane protein 3 restrict cell entry by influenza virus and lyssaviruses.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interferon-induced protein with tetratricopeptide repeats 3
    Names
    interferon-stimulated protein 60

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204395.2 → NP_001191324.1  interferon-induced protein with tetratricopeptide repeats 3

      Status: VALIDATED

      Source sequence(s)
      AEMK02000096, AK230895, AK343662, AK389734
      UniProtKB/TrEMBL
      A0A4X1UZH6, A0A8D0N196, A0A8D1I9T0, A0A8D1M1L2, A0A8D1YMU6, F1C4E1, F1SCY2, K7GMB2
      Related
      ENSSSCP00000029001.2, ENSSSCT00000035268.4
      Conserved Domains (3) summary
      sd00006
      Location:208 → 238
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:51 → 126
      TPR_12; Tetratricopeptide repeat
      cl26002
      Location:152 → 284
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010456.5 Reference Sscrofa11.1 Primary Assembly

      Range
      101214730..101225169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021071929.1 → XP_020927588.1  interferon-induced protein with tetratricopeptide repeats 3 isoform X1

      UniProtKB/TrEMBL
      A0A4X1UZH6, A0A8D0N196, A0A8D1I9T0, A0A8D1M1L2, A0A8D1YMU6, F1C4E1, F1SCY2, K7GMB2
      Related
      ENSSSCP00000011141.3, ENSSSCT00000011438.5
      Conserved Domains (3) summary
      sd00006
      Location:208 → 238
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:51 → 126
      TPR_12; Tetratricopeptide repeat
      cl26002
      Location:152 → 284
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version

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