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    CALCB calcitonin-related polypeptide beta [ Sus scrofa (pig) ]

    Gene ID: 396563, updated on 16-Nov-2023

    Summary

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    Gene symbol
    CALCB
    Gene description
    calcitonin-related polypeptide beta
    See related
    Ensembl:ENSSSCG00000035649
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    CRSP; CRSP1; CRSP-1
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See CALCB in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 2 NC_010444.4 (44315656..44367223, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 2 NC_010444.3 (47521097..47524173, complement)

    Chromosome 2 - NC_010444.4Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 23 Neighboring gene calcitonin receptor-stimulating peptide-2 Neighboring gene calcitonin receptor-stimulating peptide 1-like Neighboring gene uncharacterized LOC110259296 Neighboring gene cytochrome P450 family 2 subfamily R member 1 Neighboring gene phosphodiesterase 3B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Calcitonin receptor-stimulating peptide-1 regulates ion transport and growth of renal epithelial cell line LLC-PK1. Hamano K, et al. Biochem Biophys Res Commun, 2005 Apr 29. PMID 15781234
    2. Calcitonin receptor-stimulating peptide, a new member of the calcitonin gene-related peptide family. Its isolation from porcine brain, structure, tissue distribution, and biological activity. Katafuchi T, et al. J Biol Chem, 2003 Apr 4. PMID 12556539
    3. Genomic organization, expression and evolution of porcine CRSP1, 2, and 3. Rezaeian AH, et al. Cytogenet Genome Res, 2008. PMID 18544925
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRSP1 and CRSP2 have almost identical sequences whereas CRSP3 retains less similarity with the above genes.
      Title: Genomic organization, expression and evolution of porcine CRSP1, 2, and 3.
    2. CRSP-1 is considered to be a new regulator for the urinary ion excretion and renal epithelial cell growth
      Title: Calcitonin receptor-stimulating peptide-1 regulates ion transport and growth of renal epithelial cell line LLC-PK1.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcitonin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcitonin receptor-stimulating peptide 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213742.1 → NP_998907.1  calcitonin receptor-stimulating peptide 1 precursor

      See identical proteins and their annotated locations for NP_998907.1

      Status: PROVISIONAL

      Source sequence(s)
      AB094586
      UniProtKB/Swiss-Prot
      Q862B1
      Conserved Domains (1) summary
      pfam00214
      Location:1 → 122
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010444.4 Reference Sscrofa11.1 Primary Assembly

      Range
      44315656..44367223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021080195.1 → XP_020935854.1  calcitonin receptor-stimulating peptide 1 isoform X1

      UniProtKB/TrEMBL
      A0A287A8B3, A0A4X1TG13
      Conserved Domains (1) summary
      pfam00214
      Location:134 → 255
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    2. XM_021080183.1 → XP_020935842.1  calcitonin receptor-stimulating peptide 1 isoform X1

      UniProtKB/TrEMBL
      A0A287A8B3, A0A4X1TG13
      Conserved Domains (1) summary
      pfam00214
      Location:134 → 255
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    3. XM_021080207.1 → XP_020935866.1  calcitonin receptor-stimulating peptide 1 isoform X2

      UniProtKB/TrEMBL
      A0A4X1TG36
      Conserved Domains (1) summary
      pfam00214
      Location:51 → 172
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    4. XM_021080212.1 → XP_020935871.1  calcitonin receptor-stimulating peptide 1 isoform X3

      UniProtKB/Swiss-Prot
      Q862B1
      Conserved Domains (1) summary
      pfam00214
      Location:1 → 122
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    5. XM_021080204.1 → XP_020935863.1  calcitonin receptor-stimulating peptide 1 isoform X1

      UniProtKB/TrEMBL
      A0A287A8B3, A0A4X1TG13
      Related
      ENSSSCP00000040016.1, ENSSSCT00000047637.3
      Conserved Domains (1) summary
      pfam00214
      Location:134 → 255
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    6. XM_021080191.1 → XP_020935850.1  calcitonin receptor-stimulating peptide 1 isoform X1

      UniProtKB/TrEMBL
      A0A287A8B3, A0A4X1TG13
      Conserved Domains (1) summary
      pfam00214
      Location:134 → 255
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

    7. XM_021080192.1 → XP_020935851.1  calcitonin receptor-stimulating peptide 1 isoform X1

      UniProtKB/TrEMBL
      A0A287A8B3, A0A4X1TG13
      Conserved Domains (1) summary
      pfam00214
      Location:134 → 255
      Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q862B1.1 GenPept UniProtKB/Swiss-Prot:Q862B1

    Gene LinkOut

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