U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MFGE8 milk fat globule EGF and factor V/VIII domain containing [ Sus scrofa (pig) ]

    Gene ID: 397545, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MFGE8provided by VGNC
    Official Full Name
    milk fat globule EGF and factor V/VIII domain containingprovided by VGNC
    Primary source
    VGNC:VGNC:109463
    See related
    Ensembl:ENSSSCG00000001834
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Broad expression in ovary (RPKM 328.4), lung (RPKM 84.7) and 7 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MFGE8 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 7 NC_010449.5 (54539970..54554885, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 7 NC_010449.4 (59504870..59518390, complement)

    Chromosome 7 - NC_010449.5Genomic Context describing neighboring genes Neighboring gene myeloid-associated differentiation marker-like Neighboring gene aggrecan Neighboring gene hyaluronan and proteoglycan link protein 3 Neighboring gene uncharacterized LOC102161272 Neighboring gene abhydrolase domain containing 2, acylglycerol lipase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification by mass spectroscopy of F4ac-fimbrial-binding proteins in porcine milk and characterization of lactadherin as an inhibitor of F4ac-positive Escherichia coli attachment to intestinal villi in vitro. Shahriar F, et al. Dev Comp Immunol, 2006. PMID 16321438
    2. Molecular cloning and characterization of P47, a novel boar sperm-associated zona pellucida-binding protein homologous to a family of mammalian secretory proteins. Ensslin M, et al. Biol Reprod, 1998 Apr. PMID 9546740
    3. Transgenic pig carrying green fluorescent proteasomes. Miles EL, et al. Proc Natl Acad Sci U S A, 2013 Apr 16. PMID 23550158, Free PMC Article
    4. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The evidence suggests that lactadherin and the other F4-binding milk proteins, together with other defense components of milk, could play a role in protection of neonatal piglets against ETEC induced diarrhea.
      Title: Identification by mass spectroscopy of F4ac-fimbrial-binding proteins in porcine milk and characterization of lactadherin as an inhibitor of F4ac-positive Escherichia coli attachment to intestinal villi in vitro.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    General protein information

    Go to the top of the page Help
    Preferred Names
    lactadherin
    Names
    MFG-E8
    MFGM
    SED1
    milk fat globule-EGF factor 8 protein
    pP47 protein
    sperm surface protein SP47

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122984.1 → NP_001116456.1  lactadherin precursor

      See identical proteins and their annotated locations for NP_001116456.1

      Status: PROVISIONAL

      Source sequence(s)
      EU559724
      UniProtKB/TrEMBL
      A0A8D0JQF5, B2CZF8
      Related
      ENSSSCP00000072652.1, ENSSSCT00000083646.2
      Conserved Domains (3) summary
      smart00231
      Location:273 → 431
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:276 → 430
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00008
      Location:28 → 59
      EGF; EGF-like domain

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010449.5 Reference Sscrofa11.1 Primary Assembly

      Range
      54539970..54554885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021098306.1 → XP_020953965.1  lactadherin isoform X2

      UniProtKB/TrEMBL
      A0A5G2QNF2
      Related
      ENSSSCP00000066428.2, ENSSSCT00000083278.2
      Conserved Domains (1) summary
      cd00057
      Location:158 → 312
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    2. XM_013996945.2 → XP_013852399.1  lactadherin isoform X1

      UniProtKB/Swiss-Prot
      P79385
      Conserved Domains (3) summary
      smart00231
      Location:254 → 412
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:257 → 411
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00008
      Location:9 → 40
      EGF; EGF-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79385.2 GenPept UniProtKB/Swiss-Prot:P79385

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials