Panx1 pannexin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Panx1provided by MGI
Official Full Name: pannexin 1provided by MGI
Primary source: MGI:MGI:1860055
See related: Ensembl:ENSMUSG00000031934 AllianceGenome:MGI:1860055
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables actin filament binding activity and monoatomic anion channel activity. Involved in monoatomic anion transmembrane transport. Acts upstream of or within positive regulation of cytokine production; response to ATP; and response to ischemia. Located in plasma membrane. Is expressed in several structures, including central nervous system; foregut; limb bud; male reproductive gland or organ; and sensory organ. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human PANX1 (pannexin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in whole brain E14.5 (RPKM 36.0), CNS E18 (RPKM 33.5) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A2; 9 4.52 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (14917081..14956774, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (15005785..15045478, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cold Exposure Rejuvenates the Metabolic Phenotype of Panx1[-/-] Mice.
Title: Cold Exposure Rejuvenates the Metabolic Phenotype of Panx1(-/-) Mice.
Pannexin1 deletion in lymphatic endothelium affects lymphatic function in a sex-dependent manner.
Title: Pannexin1 deletion in lymphatic endothelium affects lymphatic function in a sex-dependent manner.
Pannexin1 Mediates Early-Life Seizure-Induced Social Behavior Deficits.
Title: Pannexin1 Mediates Early-Life Seizure-Induced Social Behavior Deficits.
PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis.
Title: PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis.
Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice.
Title: Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice.
Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain.
Title: Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain.
Global pannexin 1 deletion increases tumor-infiltrating lymphocytes in the BRAF/Pten mouse melanoma model.
Title: Global pannexin 1 deletion increases tumor-infiltrating lymphocytes in the BRAF/Pten mouse melanoma model.
Inhibition of pannexin-1 does not restore electrolyte balance in precystic Pkd1 knockout mice.
Title: Inhibition of pannexin-1 does not restore electrolyte balance in precystic Pkd1 knockout mice.
Differential activation of mouse and human Panx1 channel variants.
Title: Differential activation of mouse and human Panx1 channel variants.
Panx1 knockout promotes preneoplastic aberrant crypt foci development in a chemically induced model of mouse colon carcinogenesis.
Title: Panx1 knockout promotes preneoplastic aberrant crypt foci development in a chemically induced model of mouse colon carcinogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (171)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (10) 1 citation
Targeted (8) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ATP transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables actin binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables gap junction channel activity	ISO Inferred from Sequence Orthology more info
NOT enables gap junction hemi-channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables leak channel activity	ISO Inferred from Sequence Orthology more info
enables leak channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables monoatomic anion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables wide pore channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ATP transport	ISO Inferred from Sequence Orthology more info
involved_in ATP transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of interleukin-1 alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic anion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-1 alpha production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ATP	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ischemia	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in bleb	IEA Inferred from Electronic Annotation more info
located_in bleb	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in gap junction	ISO Inferred from Sequence Orthology more info
located_in gap junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pannexin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.