Commd9 COMM domain containing 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Commd9provided by MGI
Official Full Name: COMM domain containing 9provided by MGI
Primary source: MGI:MGI:1923751
See related: Ensembl:ENSMUSG00000027163 AllianceGenome:MGI:1923751
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1810029F08Rik
Summary: Acts upstream of or within cholesterol homeostasis. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and skeleton. Orthologous to human COMMD9 (COMM domain containing 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 24.5), whole brain E14.5 (RPKM 24.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E2; 2 54.07 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (101716607..101731984)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (101886262..101901639)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased total plasma cholesterol levels are seen in hepatic COMMD9-deficient mice.
Title: CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: COMM domain-containing protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029635.3 → NP_083911.1 COMM domain-containing protein 9

See identical proteins and their annotated locations for NP_083911.1

Status: PROVISIONAL

Source sequence(s)

AL929534

Consensus CDS

CCDS16465.1

UniProtKB/Swiss-Prot

Q3U3J2, Q7TNP5, Q811K2, Q8K2Q0, Q9D8V8

Related

ENSMUSP00000028584.8, ENSMUST00000028584.8

Conserved Domains (2) summary

cd04757
Location:90 → 197

Commd9; COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

pfam03081
Location:10 → 146

Exo70; Exo70 exocyst complex subunit