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    Y' element ATP-dependent helicase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854630, updated on 9-Dec-2024

    Summary

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    Official Full Name
    Y' element ATP-dependent helicase
    Primary source
    SGD:S000001439
    Locus tag
    YIL177C
    See related
    AllianceGenome:SGD:S000001439; FungiDB:YIL177C; VEuPathDB:YIL177C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable helicase activity. Predicted to be involved in telomere maintenance via recombination. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and primary immunodeficiency disease. Orthologous to human DHX58 (DExH-box helicase 58); RIGI (RNA sensor RIG-I); and IFIH1 (interferon induced with helicase C domain 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: IX
    Exon count:
    2
    Sequence:
    Chromosome: IX; NC_001141.2 (483..6147, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene seripauperin PAU14 Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase. Yamada M, et al. J Biol Chem, 1998 Dec 11. PMID 9837911
    2. The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturation. Bareth B, et al. Mol Cell Biol, 2013 Oct. PMID 23979592, Free PMC Article
    3. Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae. Iacovella MG, et al. Nucleic Acids Res, 2018 Sep 6. PMID 30011030, Free PMC Article
    4. The nucleotide sequence of Saccharomyces cerevisiae chromosome IX. Churcher C, et al. Nature, 1997 May 29. PMID 9169870
    5. An E3 ubiquitin ligase prevents ectopic localization of the centromeric histone H3 variant via the centromere targeting domain. Ranjitkar P, et al. Mol Cell, 2010 Nov 12. PMID 21070971, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance via recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Y' element ATP-dependent helicase
    NP_012092.1
    • Putative Y' element ATP-dependent helicase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      483..6147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179522.1 → NP_012092.1  TPA: Y' element ATP-dependent helicase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012092.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVB6, P40434
      Conserved Domains (5) summary
      COG0513
      Location:607 → 1133
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00079
      Location:909 → 1013
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam11603
      Location:5 → 88
      Sir1; Regulatory protein Sir1
      cl21455
      Location:676 → 834
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl23921
      Location:1556 → 1609
      YccJ; YccJ-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40434.1

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