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    CTSS cathepsin S [ Sus scrofa (pig) ]

    Gene ID: 100153090, updated on 3-Dec-2024

    Summary

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    Official Symbol
    CTSSprovided by VGNC
    Official Full Name
    cathepsin Sprovided by VGNC
    Primary source
    VGNC:VGNC:87079
    See related
    Ensembl:ENSSSCG00000006648
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Biased expression in spleen (RPKM 332.0), lung (RPKM 180.8) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See CTSS in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 4 NC_010446.5 (98415273..98442952)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 4 NC_010446.4 (107665975..107691575)

    Chromosome 4 - NC_010446.5Genomic Context describing neighboring genes Neighboring gene ceramide synthase 2 Neighboring gene SET domain bifurcated histone lysine methyltransferase 1 Neighboring gene aryl hydrocarbon receptor nuclear translocator Neighboring gene cathepsin K Neighboring gene HORMA domain containing 1 Neighboring gene golgi phosphoprotein 3 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Association between cathepsin L (CTSL) and cathepsin S (CTSS) polymorphisms and meat production and carcass traits in Italian Large White pigs. Fontanesi L, et al. Meat Sci, 2010 Jun. PMID 20374908
    2. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results, together with those previously reported for other genes of this family, suggest that cathepsin genes play a role in defining economically important traits in pigs.
      Title: Association between cathepsin L (CTSL) and cathepsin S (CTSS) polymorphisms and meat production and carcass traits in Italian Large White pigs.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cathepsin S

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010446.5 Reference Sscrofa11.1 Primary Assembly

      Range
      98415273..98442952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021089893.1 → XP_020945552.1  cathepsin S

      UniProtKB/TrEMBL
      A0A0B8S098, A0A4X1SEC1, A0A8D0MFR8, A0A8D0XGE0, F1SS93
      Related
      ENSSSCP00000007089.5, ENSSSCT00000007284.5
      Conserved Domains (2) summary
      smart00848
      Location:28 → 87
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:115 → 329
      Peptidase_C1; Papain family cysteine protease
    Nucleotide Protein Strain
    Heading Accession and Version

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