Prelp proline arginine-rich end leucine-rich repeat [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prelpprovided by MGI
Official Full Name: proline arginine-rich end leucine-rich repeatprovided by MGI
Primary source: MGI:MGI:2151110
See related: Ensembl:ENSMUSG00000041577 AllianceGenome:MGI:2151110
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SLRR2A; 7330409J17Rik
Summary: Predicted to enable heparin binding activity. Acts upstream of or within cellular senescence. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; connective tissue; eye; nervous system; and reproductive system. Orthologous to human PRELP (proline and arginine rich end leucine rich repeat protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 99.9), lung adult (RPKM 77.1) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 58.02 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (133838042..133857820, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (133910304..133930102, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elevated PRELP expression in heart and liver fibrosis promotes collagen production.
Title: Elevated PRELP expression in heart and liver fibrosis promotes collagen production.
PRELP promotes myocardial fibrosis and ventricular remodelling after acute myocardial infarction by the wnt/beta-catenin signalling pathway.
Title: PRELP promotes myocardial fibrosis and ventricular remodelling after acute myocardial infarction by the wnt/β-catenin signalling pathway.
Therefore, this study established a new role of PRELP in modulating beta-catenin/connexin43 pathway and osteoblast differentiation.
Title: PRELP (proline/arginine-rich end leucine-rich repeat protein) promotes osteoblastic differentiation of preosteoblastic MC3T3-E1 cells by regulating the β-catenin pathway.
when delivered via an AAV vector to the retina of mice, PRELP inhibited laser-induced choroidal neovascularization by 60%. PRELP reduced deposition of membrane attack complex in vivo by 25.5%.
Title: AAV-mediated expression of human PRELP inhibits complement activation, choroidal neovascularization and deposition of membrane attack complex in mice.
PRELP has a role in skeletal remodeling.
Title: The glycosaminoglycan-binding domain of PRELP acts as a cell type-specific NF-kappaB inhibitor that impairs osteoclastogenesis.
expressed in cartilage throughout both fetal development and post-natal life
Title: Characterization and expression of murine PRELP.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent conferring compression resistance	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular senescence	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prolargin

Names: proline-arginine-rich end leucine-rich repeat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_054077.4 → NP_473418.3 prolargin precursor

Status: VALIDATED

Source sequence(s)

AK037150, AK047480

Consensus CDS

CCDS15300.1

UniProtKB/Swiss-Prot

Q9JK53

UniProtKB/TrEMBL

Q543S0, Q8CAZ9

Related

ENSMUSP00000048803.6, ENSMUST00000048432.6

Conserved Domains (3) summary

PRK15370
Location:129 → 349

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00013
Location:68 → 103

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:100 → 123

LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

133838042..133857820 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529084.5 → XP_006529147.1 prolargin isoform X1

UniProtKB/Swiss-Prot

Q9JK53

UniProtKB/TrEMBL

Q543S0, Q8CAZ9

Conserved Domains (3) summary

PRK15370
Location:129 → 349

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00013
Location:68 → 103

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:100 → 123

LRR_RI; leucine-rich repeat [structural motif]