Npy4r neuropeptide Y receptor Y4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npy4rprovided by MGI
Official Full Name: neuropeptide Y receptor Y4provided by MGI
Primary source: MGI:MGI:105374
See related: Ensembl:ENSMUSG00000048337 AllianceGenome:MGI:105374
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Y4; PP1; Ppyr1; NPY4-R; NPYR-D; NYYR-D
Summary: Enables pancreatic polypeptide receptor activity and peptide YY receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in neuron projection and plasma membrane. Orthologous to several human genes including NPY4R (neuropeptide Y receptor Y4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 12.1), colon adult (RPKM 5.1) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 14 B; 14 20.8 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (33867603..33874376, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (34145646..34152419, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Important role of NPY-Y4R signalling in the dual control of feeding and physical activity.
Title: Important role of NPY-Y4R signalling in the dual control of feeding and physical activity.
Adipocyte reconstitution of Npy4r gene in Npy4r silenced mice promotes diet-induced obesity.
Title: Adipocyte reconstitution of Npy4r gene in Npy4r silenced mice promotes diet-induced obesity.
Genetic deletion of the Y4 receptor impaired fear extinction, an effect that was rescued by short-term fasting
Title: Hunger Promotes Fear Extinction by Activation of an Amygdala Microcircuit.
These data demonstrate glucose-regulated secretion of PP and its effects on glucagon release through PPYR1 receptors expressed by alpha-cells.
Title: Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells.
Data describe the complex interaction between Y2/Y4 receptors in control of bone mass, and suggest that the reduction in cortical bone observed in the absence of leptin is due to the anti-osteogenic effect of elevated hypothalamic NPY levels.
Title: Y2 and Y4 receptor signalling attenuates the skeletal response of central NPY.
Data from studies in knockout mice suggest that signaling through Y4 receptor prevents development of short-/long-term anxiety-/depression-like behaviour caused by acute immune challenge. Study includes comparison with Y2 receptor knockout mice.
Title: Evidence from knockout mice that neuropeptide-Y Y2 and Y4 receptor signalling prevents long-term depression-like behaviour caused by immune challenge.
Taken together, this work demonstrates the critical roles of Y2 and Y4 receptors in the regulation of body composition and energy metabolism, highlighting dual antagonism of Y2 and Y4 receptors as a potentially effective anti-obesity treatment.
Title: Y2 and Y4 receptor signaling synergistically act on energy expenditure and physical activity.
Pancreatic polypeptide enhances colonic contractile activity and fecal output through neuropeptide Y Y(4) receptor, and a neuropeptide Y Y(4) receptor agonist might offer a novel therapeutic approach to ameliorate constipation.
Title: Pancreatic polypeptide enhances colonic muscle contraction and fecal output through neuropeptide Y Y4 receptor in mice.
These findings show that pancreatic polypeptide reduces food intake predominantly via stimulation of the anorexigenic alpha-MSH signaling pathway, and that this effect is mediated by direct action on local Y4 receptors within the arcuate nucleus.
Title: Critical role of arcuate Y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice.
These findings attest to a differential role of Y2 and Y4 receptor signalling in the circadian control of behaviours that balance energy intake and energy expenditure.
Title: Evidence from knockout mice for distinct implications of neuropeptide-Y Y2 and Y4 receptors in the circadian control of locomotion, exploration, water and food intake.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

U40189 (e-PCR)
- UniSTS:125744

Ppyr1 (e-PCR), detects polymorphism
- UniSTS:144256

D1S3697 (e-PCR)
- UniSTS:474275

PMC60063P1 (e-PCR)
- UniSTS:273384

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables pancreatic polypeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables pancreatic polypeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables pancreatic polypeptide receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide YY receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide binding	IEA Inferred from Electronic Annotation more info
enables peptide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuropeptide Y receptor type 4

Names: Y4 receptor; pancreatic polypeptide receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008919.4 → NP_032945.3 neuropeptide Y receptor type 4

See identical proteins and their annotated locations for NP_032945.3

Status: VALIDATED

Source sequence(s)

BC132395

Consensus CDS

CCDS26933.1

UniProtKB/Swiss-Prot

Q3UN46, Q61041

UniProtKB/TrEMBL

Q8BZF9

Related

ENSMUSP00000056576.4, ENSMUST00000052164.4

Conserved Domains (2) summary

pfam00001
Location:58 → 322

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:52 → 174

7tm_4; Olfactory receptor