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    Apol6 apolipoprotein L 6 [ Mus musculus (house mouse) ]

    Gene ID: 71939, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Apol6provided by MGI
    Official Full Name
    apolipoprotein L 6provided by MGI
    Primary source
    MGI:MGI:1919189
    See related
    Ensembl:ENSMUSG00000033576 AllianceGenome:MGI:1919189
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310076O14Rik
    Summary
    Predicted to enable lipid binding activity. Orthologous to human APOL6 (apolipoprotein L6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 49.6), genital fat pad adult (RPKM 29.2) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Apol6 in Genome Data Viewer
    Location:
    15 D3; 15 36.39 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76929195..76941308)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (77045050..77057108)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53916 Neighboring gene predicted gene, 52199 Neighboring gene VISTA enhancer mm106 Neighboring gene STARR-seq mESC enhancer starr_39074 Neighboring gene myoglobin Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:76901831-76902180 Neighboring gene predicted gene, 24753 Neighboring gene predicted gene, 53899 Neighboring gene RNA binding protein, fox-1 homolog (C. elegans) 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ApoL6 associates with lipid droplets and disrupts Perilipin1-HSL interaction to inhibit lipolysis. Wang Y, et al. Nat Commun, 2024 Jan 2. PMID 38167864, Free PMC Article
    2. miR-10b-5p regulates 3T3-L1 cells differentiation by targeting Apol6. Tan Y, et al. Gene, 2019 Mar 1. PMID 30423386
    3. Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling. Son JS, et al. EBioMedicine, 2022 Feb. PMID 35081489, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ApoL6 associates with lipid droplets and disrupts Perilipin1-HSL interaction to inhibit lipolysis.
      Title: ApoL6 associates with lipid droplets and disrupts Perilipin1-HSL interaction to inhibit lipolysis.
    2. High APOL6 expression is associated with obesity and obesity-related cancers.
      Title: miR-10b-5p regulates 3T3-L1 cells differentiation by targeting Apol6.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    apolipoprotein L6

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163621.1 → NP_001157093.1  apolipoprotein L6 isoform 2

      See identical proteins and their annotated locations for NP_001157093.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, and uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI481097, AK144563, AL603843
      Consensus CDS
      CCDS49656.1
      UniProtKB/TrEMBL
      B7ZC55, Q9D6L7
      Related
      ENSMUSP00000118257.2, ENSMUST00000127957.8
      Conserved Domains (1) summary
      pfam05461
      Location:18 → 290
      ApoL; Apolipoprotein L

    2. NM_028010.1 → NP_082286.1  apolipoprotein L6 isoform 1

      See identical proteins and their annotated locations for NP_082286.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
      Source sequence(s)
      AI481775, AK010208, AL603843
      Consensus CDS
      CCDS49655.1
      UniProtKB/TrEMBL
      B7ZC54, Q9D6L7
      Related
      ENSMUSP00000120866.2, ENSMUST00000149569.9
      Conserved Domains (1) summary
      pfam05461
      Location:26 → 290
      ApoL; Apolipoprotein L

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76929195..76941308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521421.5 → XP_006521484.1  apolipoprotein L6 isoform X2

      See identical proteins and their annotated locations for XP_006521484.1

      UniProtKB/TrEMBL
      B7ZC54, Q9D6L7
      Conserved Domains (1) summary
      pfam05461
      Location:26 → 290
      ApoL; Apolipoprotein L

    2. XM_006521419.5 → XP_006521482.1  apolipoprotein L6 isoform X1

      See identical proteins and their annotated locations for XP_006521482.1

      UniProtKB/TrEMBL
      B7ZC55, Q9D6L7
      Conserved Domains (1) summary
      pfam05461
      Location:18 → 290
      ApoL; Apolipoprotein L

    3. XM_006521420.5 → XP_006521483.1  apolipoprotein L6 isoform X1

      See identical proteins and their annotated locations for XP_006521483.1

      UniProtKB/TrEMBL
      B7ZC55, Q9D6L7
      Conserved Domains (1) summary
      pfam05461
      Location:18 → 290
      ApoL; Apolipoprotein L
    Nucleotide Protein Strain
    Heading Accession and Version

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