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    Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 60597, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mapk8ip2provided by MGI
    Official Full Name
    mitogen-activated protein kinase 8 interacting protein 2provided by MGI
    Primary source
    MGI:MGI:1926555
    See related
    Ensembl:ENSMUSG00000022619 AllianceGenome:MGI:1926555
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IB2; Jip2; 3230402N03Rik
    Summary
    Enables kinesin binding activity. Involved in several processes, including behavioral fear response; excitatory postsynaptic potential; and regulation of neurotransmitter receptor activity. Acts upstream of or within JNK cascade. Located in cytoplasm; neuronal cell body; and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Used to study autism spectrum disorder. Orthologous to human MAPK8IP2 (mitogen-activated protein kinase 8 interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 62.8), cortex adult (RPKM 45.8) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mapk8ip2 in Genome Data Viewer
    Location:
    15 E3; 15 44.92 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89338114..89346650)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89453911..89462447)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted readthrough transcript (NMD candidate), 44502 Neighboring gene RIKEN cDNA C730034F03 gene Neighboring gene STARR-positive B cell enhancer ABC_E7406 Neighboring gene STARR-positive B cell enhancer ABC_E9159 Neighboring gene choline kinase beta Neighboring gene RIKEN cDNA C230037L18 gene Neighboring gene STARR-seq mESC enhancer starr_39466 Neighboring gene arylsulfatase A Neighboring gene SH3 and multiple ankyrin repeat domains 3 Neighboring gene predicted gene 15609

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables JUN kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP-kinase scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP-kinase scaffold activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP-kinase scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinesin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nonassociative learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of stress-activated MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of AMPA receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of NMDA receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    C-Jun-amino-terminal kinase-interacting protein 2
    Names
    IB-2
    JIP-2
    JNK MAP kinase scaffold protein 2
    JNK-interacting protein 2
    islet-brain-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021921.3NP_068740.3  C-Jun-amino-terminal kinase-interacting protein 2

      See identical proteins and their annotated locations for NP_068740.3

      Status: VALIDATED

      Source sequence(s)
      AC137513, AK158968, BC029704, CA317486
      Consensus CDS
      CCDS27752.1
      UniProtKB/Swiss-Prot
      Q9CXI4, Q9ERE9
      UniProtKB/TrEMBL
      Q548W8, Q6PIT2
      Related
      ENSMUSP00000023291.6, ENSMUST00000023291.6
      Conserved Domains (2) summary
      cd11942
      Location:614668
      SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
      cd01212
      Location:685830
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      89338114..89346650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)