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    Card6 caspase recruitment domain family, member 6 [ Mus musculus (house mouse) ]

    Gene ID: 239319, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Card6provided by MGI
    Official Full Name
    caspase recruitment domain family, member 6provided by MGI
    Primary source
    MGI:MGI:3032959
    See related
    Ensembl:ENSMUSG00000041849 AllianceGenome:MGI:3032959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D730008L15
    Summary
    Predicted to act upstream of or within regulation of canonical NF-kappaB signal transduction. Predicted to be located in cytoplasm. Is expressed in heart ventricle; lung; upper arm muscle; upper leg muscle; and vertebral axis musculature. Orthologous to human CARD6 (caspase recruitment domain family member 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 1.0), testis adult (RPKM 0.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Card6 in Genome Data Viewer
    Location:
    15 A1; 15 1.99 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (5126402..5146762, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (5096920..5116562, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene complement component 7 Neighboring gene predicted gene, 25652 Neighboring gene caspase recruitment domain family, member 6 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8583 Neighboring gene STARR-positive B cell enhancer ABC_E1171 Neighboring gene small nucleolar RNA, C/D box 72 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d pseudogene Neighboring gene ribosomal protein L37

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased macrophage activation mediated by caspase recruitment domain 6 knockdown through negatively targeting AMPK. Chen F, et al. Biochem Biophys Res Commun, 2020 Apr 30. PMID 32102753
    2. Targeting CARD6 attenuates spinal cord injury (SCI) in mice through inhibiting apoptosis, inflammation and oxidative stress associated ROS production. Wang JL, et al. Aging (Albany NY), 2019 Dec 16. PMID 31841440, Free PMC Article
    3. Caspase recruitment domain 6 protects against cardiac hypertrophy in response to pressure overload. Li L, et al. Hypertension, 2014 Jul. PMID 24777975
    4. CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation. Dufner A, et al. Mol Cell Biol, 2008 Mar. PMID 18160713, Free PMC Article
    5. CARD6 protects against collagen-induced rheumatoid arthritis in mice through attenuating the inflammatory response and joint destruction via suppression of TNFR1/TRAF2 signaling. Zhao M, et al. Biochem Biophys Res Commun, 2020 Jun 11. PMID 32317187

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CARD6 protects against collagen-induced rheumatoid arthritis in mice through attenuating the inflammatory response and joint destruction via suppression of TNFR1/TRAF2 signaling.
      Title: CARD6 protects against collagen-induced rheumatoid arthritis in mice through attenuating the inflammatory response and joint destruction via suppression of TNFR1/TRAF2 signaling.
    2. Increased macrophage activation mediated by caspase recruitment domain 6 knockdown through negatively targeting AMPK.
      Title: Increased macrophage activation mediated by caspase recruitment domain 6 knockdown through negatively targeting AMPK.
    3. Targeting CARD6 attenuates spinal cord injury (SCI) in mice through inhibiting apoptosis, inflammation and oxidative stress associated ROS production.
      Title: Targeting CARD6 attenuates spinal cord injury (SCI) in mice through inhibiting apoptosis, inflammation and oxidative stress associated ROS production.
    4. CARD6 is a novel protective factor against hepatic I/R injury that suppresses inflammation and liver cell death by inhibiting the ASK1 signaling pathway.
      Title: Caspase recruitment domain 6 protects against hepatic ischemia/reperfusion injury by suppressing ASK1.
    5. Gain-of-function and loss-of-function Card6 mouse models demonstrated that Card6 protected mice from insulin resistance, hepatic steatosis, and inflammatory responses upon high-fat diet administration. Mechanistically, Card6 interacted with and inhibited apoptosis signal-regulating kinase 1 (Ask1) and its subsequent downstream c-Jun N-terminal kinase/p38 signaling.
      Title: Caspase Recruitment Domain Protein 6 Protects Against Hepatic Steatosis and Insulin Resistance by Suppressing Apoptosis Signal-Regulating Kinase 1.
    6. these data indicated that CARD6 serves as a novel cardioprotective factor via negative regulation of MEK kinase-1-dependent MEK-ERK1/2 and JNK1/2 signaling
      Title: Caspase recruitment domain 6 protects against cardiac hypertrophy in response to pressure overload.
    7. CARD6 is a regulator of NF-kappaB activation that modulates the functions of RICK protein
      Title: Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    caspase recruitment domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163138.1 → NP_001156610.1  caspase recruitment domain-containing protein 6

      See identical proteins and their annotated locations for NP_001156610.1

      Status: VALIDATED

      Source sequence(s)
      AC131919
      Consensus CDS
      CCDS49573.1
      UniProtKB/TrEMBL
      E9PWH2, Q8BWE0
      Related
      ENSMUSP00000112833.3, ENSMUST00000118365.3
      Conserved Domains (2) summary
      PHA03247
      Location:789 → 1166
      PHA03247; large tegument protein UL36; Provisional
      pfam00619
      Location:9 → 88
      CARD; Caspase recruitment domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      5126402..5146762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519987.5 → XP_006520050.2  caspase recruitment domain-containing protein 6 isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:939 → 1316
      PHA03247; large tegument protein UL36; Provisional
      cd01671
      Location:161 → 229
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain

    2. XM_030248533.1 → XP_030104393.1  caspase recruitment domain-containing protein 6 isoform X2

      UniProtKB/TrEMBL
      E9PWH2, Q8BWE0
      Conserved Domains (2) summary
      PHA03247
      Location:789 → 1166
      PHA03247; large tegument protein UL36; Provisional
      pfam00619
      Location:9 → 88
      CARD; Caspase recruitment domain
    Nucleotide Protein Strain
    Heading Accession and Version

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