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    Dvl3 dishevelled segment polarity protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 13544, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dvl3provided by MGI
    Official Full Name
    dishevelled segment polarity protein 3provided by MGI
    Primary source
    MGI:MGI:108100
    See related
    Ensembl:ENSMUSG00000003233 AllianceGenome:MGI:108100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    b2b2866Clo
    Summary
    Enables protein-macromolecule adaptor activity. Involved in canonical Wnt signaling pathway and non-canonical Wnt signaling pathway. Acts upstream of or within Wnt signaling pathway, planar cell polarity pathway; cochlea morphogenesis; and outflow tract septum morphogenesis. Located in cytoplasm. Part of Wnt signalosome. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 3 and lung cancer. Orthologous to human DVL3 (dishevelled segment polarity protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 25.9), CNS E14 (RPKM 23.6) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dvl3 in Genome Data Viewer
    Location:
    16 A3; 16 12.46 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20335694..20352763)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20516949..20534013)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41432 Neighboring gene STARR-seq mESC enhancer starr_40326 Neighboring gene STARR-seq mESC enhancer starr_40327 Neighboring gene eukaryotic translation initiation factor 2B, subunit 5 epsilon Neighboring gene STARR-seq mESC enhancer starr_40328 Neighboring gene predicted gene, 16618 Neighboring gene STARR-positive B cell enhancer ABC_E1488 Neighboring gene adaptor-related protein complex 2, mu 1 subunit Neighboring gene mitochondrial ribosomal protein S18B pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables frizzled binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in Wnt signaling pathway, planar cell polarity pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cochlea morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within heart morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in midbrain dopaminergic neuron differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in non-canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in non-canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in non-canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in non-canonical Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within outflow tract septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection arborization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Wnt signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    segment polarity protein dishevelled homolog DVL-3
    Names
    dishevelled 3, dsh homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347176.2NP_001334105.1  segment polarity protein dishevelled homolog DVL-3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087898
      Consensus CDS
      CCDS84210.1
      UniProtKB/TrEMBL
      E9Q967
      Related
      ENSMUSP00000130925.2, ENSMUST00000171572.9
      Conserved Domains (5) summary
      smart00021
      Location:182
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:247334
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:413496
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:97245
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:500706
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
    2. NM_001416758.1NP_001403687.1  segment polarity protein dishevelled homolog DVL-3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC087898
    3. NM_001416759.1NP_001403688.1  segment polarity protein dishevelled homolog DVL-3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087898
    4. NM_001416760.1NP_001403689.1  segment polarity protein dishevelled homolog DVL-3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC087898
      UniProtKB/TrEMBL
      E9Q150
      Related
      ENSMUSP00000126082.2, ENSMUST00000171774.2
    5. NM_007889.4NP_031915.2  segment polarity protein dishevelled homolog DVL-3 isoform 1

      See identical proteins and their annotated locations for NP_031915.2

      Status: VALIDATED

      Source sequence(s)
      AC087898
      Consensus CDS
      CCDS37287.1
      UniProtKB/Swiss-Prot
      G5E820, Q61062
      Related
      ENSMUSP00000003318.6, ENSMUST00000003318.13
      Conserved Domains (5) summary
      smart00021
      Location:182
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:247334
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:413496
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:97245
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:500706
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal

    RNA

    1. NR_184391.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087898

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      20335694..20352763
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521780.4XP_006521843.1  segment polarity protein dishevelled homolog DVL-3 isoform X1

      Conserved Domains (5) summary
      smart00021
      Location:182
      DAX; Domain present in Dishevelled and axin
      cd00992
      Location:246333
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04438
      Location:412495
      DEP_dishevelled; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in dishevelled-like proteins. Dishevelled-like proteins play a key role in the transduction of the Wnt signal from the cell surface to the nucleus, which in turn is an important regulatory pathway ...
      pfam02377
      Location:97244
      Dishevelled; Dishevelled specific domain
      pfam12316
      Location:499705
      Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal