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    Odad2 outer dynein arm docking complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 74934, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Odad2provided by MGI
    Official Full Name
    outer dynein arm docking complex subunit 2provided by MGI
    Primary source
    MGI:MGI:1922184
    See related
    Ensembl:ENSMUSG00000061802 AllianceGenome:MGI:1922184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Armc4; b2b643Clo; b2b227.1Clo; 4930463I21Rik
    Summary
    Acts upstream of or within several processes, including determination of left/right symmetry; outer dynein arm assembly; and ventricular system development. Predicted to be located in axoneme and ciliary base. Is expressed in node. Used to study Kartagener syndrome; primary ciliary dyskinesia 23; and visceral heterotaxy. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 23. Orthologous to human ODAD2 (outer dynein arm docking complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 5.0) and ovary adult (RPKM 0.3) See more
    Orthologs
    human all
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    Genomic context

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    See Odad2 in Genome Data Viewer
    Location:
    18 A1; 18 4.53 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (7088233..7298272, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (7088233..7298273, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene mohawk homeobox Neighboring gene predicted gene, 46633 Neighboring gene STARR-seq mESC enhancer starr_43731 Neighboring gene predicted gene 10350 Neighboring gene predicted gene, 18581 Neighboring gene STARR-seq mESC enhancer starr_43732 Neighboring gene predicted gene, 34979 Neighboring gene STARR-seq mESC enhancer starr_43733 Neighboring gene membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) Neighboring gene STARR-seq mESC enhancer starr_43734 Neighboring gene STARR-positive B cell enhancer mm9_chr18:7497579-7497879 Neighboring gene STARR-seq mESC enhancer starr_43735 Neighboring gene MAD2 mitotic arrest deficient-like 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression. Lonergan KM, et al. Am J Respir Cell Mol Biol, 2006 Dec. PMID 16809635
    2. CFAP61 is required for sperm flagellum formation and male fertility in human and mouse. Liu S, et al. Development, 2021 Dec 1. PMID 34792097
    3. ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry. Hjeij R, et al. Am J Hum Genet, 2013 Aug 8. PMID 23849778, Free PMC Article
    4. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504
    5. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cilium movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within outer dynein arm assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within outer dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cilium beat frequency IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cilium beat frequency ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ventricular system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary base ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    outer dynein arm-docking complex subunit 2
    Names
    armadillo repeat containing 4
    armadillo repeat-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357492.1 → NP_001344421.1  outer dynein arm-docking complex subunit 2

      Status: VALIDATED

      Source sequence(s)
      BB573298, BB679543, BC158097
      Consensus CDS
      CCDS37729.1
      UniProtKB/Swiss-Prot
      B2RY50, Q9CUL6
      Related
      ENSMUSP00000157197.2, ENSMUST00000234788.2
      Conserved Domains (4) summary
      PLN03200
      Location:618 → 855
      PLN03200; cellulose synthase-interactive protein; Provisional
      COG5064
      Location:750 → 1035
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00044
      Location:919 → 947
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:876 → 901
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      7088233..7298272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526313.5 → XP_006526376.1  outer dynein arm-docking complex subunit 2 isoform X3

      Conserved Domains (4) summary
      PLN03200
      Location:473 → 710
      PLN03200; cellulose synthase-interactive protein; Provisional
      COG5064
      Location:605 → 890
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00044
      Location:774 → 802
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:731 → 756
      ARM; armadillo repeat [structural motif]

    2. XM_036161300.1 → XP_036017193.1  outer dynein arm-docking complex subunit 2 isoform X2

      Conserved Domains (4) summary
      PLN03200
      Location:494 → 731
      PLN03200; cellulose synthase-interactive protein; Provisional
      COG5064
      Location:626 → 911
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00044
      Location:795 → 823
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:752 → 777
      ARM; armadillo repeat [structural motif]

    3. XM_030250622.1 → XP_030106482.1  outer dynein arm-docking complex subunit 2 isoform X1

      UniProtKB/Swiss-Prot
      B2RY50, Q9CUL6
      Related
      ENSMUSP00000080028.5, ENSMUST00000081275.5
      Conserved Domains (4) summary
      PLN03200
      Location:618 → 855
      PLN03200; cellulose synthase-interactive protein; Provisional
      COG5064
      Location:750 → 1035
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00044
      Location:919 → 947
      HEAT; HEAT repeat [structural motif]
      sd00043
      Location:876 → 901
      ARM; armadillo repeat [structural motif]

    4. XM_011247017.1 → XP_011245319.1  outer dynein arm-docking complex subunit 2 isoform X5

      Conserved Domains (3) summary
      PLN03200
      Location:167 → 404
      PLN03200; cellulose synthase-interactive protein; Provisional
      COG5064
      Location:299 → 584
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:459 → 488
      ARM; armadillo repeat [structural motif]

    5. XM_011247016.1 → XP_011245318.1  outer dynein arm-docking complex subunit 2 isoform X4

      Conserved Domains (3) summary
      PLN03200
      Location:312 → 549
      PLN03200; cellulose synthase-interactive protein; Provisional
      COG5064
      Location:444 → 729
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:604 → 633
      ARM; armadillo repeat [structural motif]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081393.1: Suppressed sequence

      Description
      NM_001081393.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RY50.1 GenPept UniProtKB/Swiss-Prot:B2RY50

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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