Ms4a8a membrane-spanning 4-domains, subfamily A, member 8A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ms4a8aprovided by MGI
Official Full Name: membrane-spanning 4-domains, subfamily A, member 8Aprovided by MGI
Primary source: MGI:MGI:1927657
See related: Ensembl:ENSMUSG00000024730 AllianceGenome:MGI:1927657
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ms4a8; CD20L5; 2010004L09Rik
Summary: Predicted to be involved in cell surface receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in rectum and stomach. Orthologous to human MS4A8 (membrane spanning 4-domains A8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 248.0), large intestine adult (RPKM 219.6) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 7.62 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (11044835..11058467, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (11067471..11081103, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MS4A8A is a novel differentiation marker of the intestinal epithelium that supports the maintenance of a physiological barrier function in the gut by modulating the transcriptome and by conferring an increased resistance to reactive oxygen species.
Title: Identification of the novel differentiation marker MS4A8B and its murine homolog MS4A8A in colonic epithelial cells lost during neoplastic transformation in human colon.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

AI481240 (e-PCR)
- UniSTS:160799

NoName (e-PCR)
- UniSTS:490599

NoName (e-PCR)
- UniSTS:495524

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: membrane-spanning 4-domains subfamily A member 8

Names: CD20 antigen-like 5; MS4a8B protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.