Plp2 proteolipid protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plp2provided by MGI
Official Full Name: proteolipid protein 2provided by MGI
Primary source: MGI:MGI:1298382
See related: Ensembl:ENSMUSG00000031146 AllianceGenome:MGI:1298382
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mIMA4
Summary: Predicted to enable chemokine binding activity. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in central nervous system; cranium; sensory organ; and stomach. Orthologous to human PLP2 (proteolipid protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in genital fat pad adult (RPKM 122.4), colon adult (RPKM 120.2) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 3.45 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (7534180..7537629, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (7667941..7671390, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLP2 enhanced proliferation, adhesion, invasion, and MMP-2 secretion in vitro, and tumor metastasis in vivo.
Title: Proteolipid protein 2 is associated with melanoma metastasis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136577 (e-PCR)
- UniSTS:210557

NoName (e-PCR)
- UniSTS:495292

NoName (e-PCR)
- UniSTS:234433

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemokine binding	ISO Inferred from Sequence Orthology more info
enables chemokine binding	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proteolipid protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.