Arhgap11a Rho GTPase activating protein 11A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgap11aprovided by MGI
Official Full Name: Rho GTPase activating protein 11Aprovided by MGI
Primary source: MGI:MGI:2444300
See related: Ensembl:ENSMUSG00000041219 AllianceGenome:MGI:2444300
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0013; 6530401L14Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in positive regulation of GTPase activity. Predicted to be located in mitochondrial matrix and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to several human genes including ARHGAP11A (Rho GTPase activating protein 11A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 20.9), liver E14 (RPKM 13.4) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E4; 2 57.47 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (113661837..113679006, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (113831492..113848661, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ArhGAP11A mediates amyloid-beta generation and neuropathology in an Alzheimer's disease-like mouse model.
Title: ArhGAP11A mediates amyloid-β generation and neuropathology in an Alzheimer's disease-like mouse model.
Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development.
Title: Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Arhgap11a (e-PCR), detects polymorphism
- UniSTS:506737

NoName (e-PCR)
- UniSTS:234490

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: rho GTPase-activating protein 11A

Names: GAP (1-12); rho-type GTPase-activating protein 11A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181416.3 → NP_852081.2 rho GTPase-activating protein 11A

See identical proteins and their annotated locations for NP_852081.2

Status: VALIDATED

Source sequence(s)

AL772405, BC058105, BU052980

Consensus CDS

CCDS16562.1

UniProtKB/Swiss-Prot

A2AL17, Q6ZQL1, Q80Y19

Related

ENSMUSP00000099604.2, ENSMUST00000102545.8

Conserved Domains (2) summary

cd04394
Location:46 → 246

RhoGAP-ARHGAP11A; RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing ...

pfam16609
Location:371 → 464

SH3-RhoG_link; SH3-RhoGEF linking unstructured region