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    Epha5 Eph receptor A5 [ Mus musculus (house mouse) ]

    Gene ID: 13839, updated on 3-Dec-2024

    Summary

    Official Symbol
    Epha5provided by MGI
    Official Full Name
    Eph receptor A5provided by MGI
    Primary source
    MGI:MGI:99654
    See related
    Ensembl:ENSMUSG00000029245 AllianceGenome:MGI:99654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    bsk; Cek7; Ehk1; Els1; Hek7; Rek7
    Summary
    Enables GPI-linked ephrin receptor activity. Involved in several processes, including ephrin receptor signaling pathway; nervous system development; and regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus and cellular response to forskolin. Located in adherens junction and cell periphery. Is expressed in several structures, including alimentary system; future midbrain; genitourinary system; nervous system; and sensory organ. Orthologous to human EPHA5 (EPH receptor A5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 9.2), frontal lobe adult (RPKM 7.7) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Epha5 in Genome Data Viewer
    Location:
    5 E1; 5 43.0 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (84199024..84565677, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (84054761..84417818, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13526 Neighboring gene mitochondrial ribosomal protein L12 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13527 Neighboring gene STARR-seq mESC enhancer starr_13528 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13529 Neighboring gene high mobility group nucleosomal binding domain 2, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_13530 Neighboring gene STARR-seq mESC enhancer starr_13531 Neighboring gene STARR-seq mESC enhancer starr_13532 Neighboring gene predicted gene, 42163 Neighboring gene WD repeat domain 12 pseudogene Neighboring gene phosphoglycerate kinase 1, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GPI-linked ephrin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables boss receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables brain-derived neurotrophic factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ephrin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ephrin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables epidermal growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hepatocyte growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin-like growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables macrophage colony-stimulating factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables placental growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor alpha-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor beta-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase collagen receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables stem cell factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane-ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables vascular endothelial growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Kit signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in brain-derived neurotrophic factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cellular response to follicle-stimulating hormone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to forskolin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in collagen-activated tyrosine kinase receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hepatocyte growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hippocampus development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macrophage colony-stimulating factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in platelet-derived growth factor receptor-alpha signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet-derived growth factor receptor-beta signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of CREB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor-1 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ephrin type-A receptor 5
    Names
    EPH homology kinase 1
    brain-specific kinase
    eck-like sequence 1
    NP_001389678.1
    NP_001389679.1
    NP_001389680.1
    NP_001389681.1
    NP_001389682.1
    NP_001389683.1
    NP_001389684.1
    NP_001389685.1
    NP_001389686.1
    NP_001389687.1
    NP_001389688.1
    NP_001389689.1
    NP_001389690.1
    NP_031963.2
    XP_006534832.1
    XP_030109983.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402749.1NP_001389678.1  ephrin type-A receptor 5 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC101956, AC114638, AC129220, AC132597
      UniProtKB/TrEMBL
      E9PUP9
      Related
      ENSMUSP00000109033.2, ENSMUST00000113406.8
    2. NM_001402750.1NP_001389679.1  ephrin type-A receptor 5 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC101956, AC114638, AC129220, AC132597
      UniProtKB/TrEMBL
      E9PUP9, E9PUQ2
      Related
      ENSMUSP00000109026.2, ENSMUST00000113399.6
    3. NM_001402751.1NP_001389680.1  ephrin type-A receptor 5 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC101956, AC114638, AC129220, AC132597
      UniProtKB/TrEMBL
      E9PUP9
    4. NM_001402752.1NP_001389681.1  ephrin type-A receptor 5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC101956, AC114638, AC129220, AC132597
      UniProtKB/TrEMBL
      E9PUP9
    5. NM_001402753.1NP_001389682.1  ephrin type-A receptor 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC101956, AC114638, AC129220, AC132597
      UniProtKB/TrEMBL
      E9PUP9
    6. NM_001402754.1NP_001389683.1  ephrin type-A receptor 5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC101956, AC114638, AC129220, AC132597
      UniProtKB/TrEMBL
      E9PUP9
    7. NM_001402755.1NP_001389684.1  ephrin type-A receptor 5 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC101956, AC114638, AC129220, AC132597
      UniProtKB/TrEMBL
      E9PUP9, E9PUQ4
      Related
      ENSMUSP00000109025.2, ENSMUST00000113398.8
    8. NM_001402756.1NP_001389685.1  ephrin type-A receptor 5 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC101956, AC114638, AC129220, AC132597
      UniProtKB/TrEMBL
      E9PUP9
    9. NM_001402757.1NP_001389686.1  ephrin type-A receptor 5 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC101956, AC114638, AC129220, AC132597
      UniProtKB/TrEMBL
      E9PUP9
    10. NM_001402758.1NP_001389687.1  ephrin type-A receptor 5 isoform 11 precursor

      Status: VALIDATED

      Source sequence(s)
      AC101956, AC114638, AC129220, AC132597
      UniProtKB/TrEMBL
      E9PUP9
    11. NM_001402759.1NP_001389688.1  ephrin type-A receptor 5 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC101956, AC114638, AC129220, AC132597
      UniProtKB/TrEMBL
      E9PUP9
    12. NM_001402760.1NP_001389689.1  ephrin type-A receptor 5 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC101956, AC114638, AC129220, AC132597
      UniProtKB/TrEMBL
      E9PUP9, Q6PFV6
      Related
      ENSMUSP00000109028.2, ENSMUST00000113401.4
    13. NM_001402761.1NP_001389690.1  ephrin type-A receptor 5 isoform 14 precursor

      Status: VALIDATED

      Source sequence(s)
      AC101956, AC129220, AC132597
    14. NM_007937.3NP_031963.2  ephrin type-A receptor 5 isoform 8 precursor

      See identical proteins and their annotated locations for NP_031963.2

      Status: VALIDATED

      Source sequence(s)
      AC101956, AC114638, AC129220, AC132597
      Consensus CDS
      CCDS19376.1
      UniProtKB/Swiss-Prot
      E9QPV2, Q60629
      UniProtKB/TrEMBL
      E9PUP9
      Related
      ENSMUSP00000060646.9, ENSMUST00000053733.15
      Conserved Domains (7) summary
      cd09546
      Location:804869
      SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
      smart00454
      Location:808866
      SAM; Sterile alpha motif
      cd00063
      Location:307397
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:509775
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam07714
      Location:514771
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:417509
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:62234
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      84199024..84565677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534769.3XP_006534832.1  ephrin type-A receptor 5 isoform X1

      UniProtKB/TrEMBL
      E9PUP9, E9PUQ0
      Related
      ENSMUSP00000109030.2, ENSMUST00000113403.8
      Conserved Domains (5) summary
      cd09546
      Location:9681033
      SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
      cd00063
      Location:471561
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:673939
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam14575
      Location:581673
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:62234
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    2. XM_030254123.2XP_030109983.1  ephrin type-A receptor 5 isoform X3

      UniProtKB/TrEMBL
      E9PUP9
      Conserved Domains (5) summary
      cd09546
      Location:897962
      SAM_EPH-A5; SAM domain of EPH-A5 subfamily of tyrosine kinase receptors
      cd00063
      Location:400490
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:602868
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam14575
      Location:510602
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:1163
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors