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    Kcnd2 potassium voltage-gated channel, Shal-related family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 16508, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcnd2provided by MGI
    Official Full Name
    potassium voltage-gated channel, Shal-related family, member 2provided by MGI
    Primary source
    MGI:MGI:102663
    See related
    Ensembl:ENSMUSG00000060882 AllianceGenome:MGI:102663
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kv4.2; Gm52855
    Summary
    Enables A-type (transient outward) potassium channel activity and voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including locomotor rhythm; neuronal action potential; and potassium ion transmembrane transport. Located in dendritic spine; neuronal cell body; and plasma membrane. Part of voltage-gated potassium channel complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization membrane. Is expressed in several structures, including heart; hindlimb digit; metanephros; nervous system; and sensory organ. Orthologous to human KCND2 (potassium voltage-gated channel subfamily D member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 27.7), frontal lobe adult (RPKM 12.3) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kcnd2 in Genome Data Viewer
    Location:
    6 A2- A3.1; 6 8.49 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (21212101..21729804)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (21215346..21729805)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15298 Neighboring gene STARR-seq mESC enhancer starr_15299 Neighboring gene predicted gene, 23960 Neighboring gene predicted gene, 26373 Neighboring gene STARR-seq mESC enhancer starr_15300 Neighboring gene STARR-seq mESC enhancer starr_15301 Neighboring gene STARR-seq mESC enhancer starr_15302 Neighboring gene STARR-seq mESC enhancer starr_15303 Neighboring gene tetraspanin 12 Neighboring gene predicted gene, 30270 Neighboring gene STARR-positive B cell enhancer ABC_E676 Neighboring gene STARR-positive B cell enhancer ABC_E6418 Neighboring gene inhibitor of growth family, member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1044

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables A-type (transient outward) potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables A-type (transient outward) potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables A-type (transient outward) potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables A-type (transient outward) potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables A-type (transient outward) potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables voltage-gated potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle cell action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in potassium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of heart contraction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Kv4.2-KChIP2 channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in T-tubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    A-type voltage-gated potassium channel KCND2; potassium voltage-gated channel subfamily D member 2
    Names
    voltage-gated potassium channel subunit Kv4.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019697.4NP_062671.1  A-type voltage-gated potassium channel KCND2

      See identical proteins and their annotated locations for NP_062671.1

      Status: VALIDATED

      Source sequence(s)
      BC079667, BY279027, CB520748
      Consensus CDS
      CCDS19934.1
      UniProtKB/Swiss-Prot
      Q8BSK3, Q8CHB7, Q9JJ60, Q9Z0V2
      Related
      ENSMUSP00000080257.6, ENSMUST00000081542.6
      Conserved Domains (6) summary
      smart00225
      Location:43140
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:216415
      Ion_trans; Ion transport protein
      pfam02214
      Location:43132
      BTB_2; BTB/POZ domain
      pfam07885
      Location:331411
      Ion_trans_2; Ion channel
      pfam11601
      Location:328
      Shal-type; Shal-type voltage-gated potassium channels
      pfam11879
      Location:445546
      DUF3399; Domain of unknown function (DUF3399)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      21212101..21729804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165884.1XP_036021777.1  potassium voltage-gated channel subfamily D member 2 isoform X1

      Conserved Domains (2) summary
      cl38908
      Location:6144
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam00520
      Location:184373
      Ion_trans; Ion transport protein