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    Dmkn dermokine [ Mus musculus (house mouse) ]

    Gene ID: 73712, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dmknprovided by MGI
    Official Full Name
    dermokineprovided by MGI
    Primary source
    MGI:MGI:1920962
    See related
    Ensembl:ENSMUSG00000060962 AllianceGenome:MGI:1920962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SK30; SK89; cI-36; C130074A08; 1110014F24Rik
    Summary
    Acts upstream of or within cornified envelope assembly. Located in extracellular space. Is expressed in epidermis; nasal cavity epithelium; nose; posterior naris epithelium; and skin. Orthologous to human DMKN (dermokine). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach adult (RPKM 182.1), lung adult (RPKM 34.0) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dmkn in Genome Data Viewer
    Location:
    7 B1; 7 19.24 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30463181..30480491)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30763756..30781066)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11349 Neighboring gene transmembrane protein 147 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Neighboring gene suprabasin Neighboring gene STARR-seq mESC enhancer starr_18532 Neighboring gene keratinocyte differentiation associated protein Neighboring gene predicted gene, 32236 Neighboring gene free fatty acid receptor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cornified envelope assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cornified envelope assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dermokine
    Names
    epidermis-specific secreted protein SK30/SK89

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166173.1NP_001159645.1  dermokine isoform c precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC165340, AK081753
      Consensus CDS
      CCDS52183.1
      UniProtKB/Swiss-Prot
      Q6E0U6, Q6P253, Q6SZJ9, Q9D1D0
      UniProtKB/TrEMBL
      E9Q2P1
      Related
      ENSMUSP00000129031.2, ENSMUST00000165887.8
      Conserved Domains (1) summary
      PRK13875
      Location:22155
      PRK13875; conjugal transfer protein TrbL; Provisional
    2. NM_001166174.1NP_001159646.1  dermokine isoform d precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 3.
      Source sequence(s)
      AC165340, AK081753, BC064724
      Consensus CDS
      CCDS52184.1
      UniProtKB/Swiss-Prot
      Q6E0U6, Q6P253, Q6SZJ9, Q9D1D0
      UniProtKB/TrEMBL
      E9QLW8
      Related
      ENSMUSP00000082831.5, ENSMUST00000085688.11
      Conserved Domains (1) summary
      PRK13875
      Location:22155
      PRK13875; conjugal transfer protein TrbL; Provisional
    3. NM_001369359.1NP_001356288.1  dermokine isoform e precursor

      Status: VALIDATED

      Source sequence(s)
      AC165340
      UniProtKB/Swiss-Prot
      Q6E0U6, Q6P253, Q6SZJ9, Q9D1D0
      Conserved Domains (1) summary
      PRK13875
      Location:22155
      PRK13875; conjugal transfer protein TrbL; Provisional
    4. NM_028618.2NP_082894.1  dermokine isoform a precursor

      See identical proteins and their annotated locations for NP_082894.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (1, also called alpha) has the same N- and C-termini but is shorter compared to isoform 3.
      Source sequence(s)
      AC165340, AK003695
      Consensus CDS
      CCDS39893.1
      UniProtKB/Swiss-Prot
      Q6P253
      Related
      ENSMUSP00000042300.8, ENSMUST00000041703.10
    5. NM_172899.4NP_766487.3  dermokine isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (2, also called beta) has a shorter and distinct N-terminus compared to isoform 3.
      Source sequence(s)
      AC165340, AK081753, BC064724
      Consensus CDS
      CCDS39892.1
      UniProtKB/Swiss-Prot
      Q6E0U6, Q6P253, Q6SZJ9, Q9D1D0
      UniProtKB/TrEMBL
      E9QLW7
      Related
      ENSMUSP00000082834.5, ENSMUST00000085691.11
      Conserved Domains (1) summary
      PRK13875
      Location:22155
      PRK13875; conjugal transfer protein TrbL; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30463181..30480491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)