P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: P2ry6provided by MGI
Official Full Name: pyrimidinergic receptor P2Y, G-protein coupled, 6provided by MGI
Primary source: MGI:MGI:2673874
See related: Ensembl:ENSMUSG00000048779 AllianceGenome:MGI:2673874
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P2Y6; 2010204J23Rik
Summary: Enables G protein-coupled UDP receptor activity. Acts upstream of or within cellular response to organic cyclic compound; cellular response to prostaglandin E stimulus; and transepithelial chloride transport. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Predicted to be active in plasma membrane. Is expressed in dermomyotome and musculature. Orthologous to human P2RY6 (pyrimidinergic receptor P2Y6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in colon adult (RPKM 37.0), lung adult (RPKM 23.5) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.46 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (100586837..100628528, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (100937630..100975498, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microglial P2Y6 calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis.
Title: Microglial P2Y(6) calcium signaling promotes phagocytosis and shapes neuroimmune responses in epileptogenesis.
Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cbeta/store-operated calcium entry/calreticulin/scavenger receptor A pathways.
Title: Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase Cβ/store-operated calcium entry/calreticulin/scavenger receptor A pathways.
Knockout of Purinergic P2Y6 Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis.
Title: Knockout of Purinergic P2Y(6) Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis.
Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and Suppresses Allergic Lung Inflammation.
Title: Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and Suppresses Allergic Lung Inflammation.
P2RY6 Has a Critical Role in Mouse Skin Carcinogenesis by Regulating the YAP and beta-Catenin Signaling Pathways.
Title: P2RY6 Has a Critical Role in Mouse Skin Carcinogenesis by Regulating the YAP and β-Catenin Signaling Pathways.
Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression.
Title: Redox-dependent internalization of the purinergic P2Y(6) receptor limits colitis progression.
Astrocyte-mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome.
Title: Astrocyte-mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome.
The microglial P2Y6 receptor mediates neuronal loss and memory deficits in neurodegeneration.
Title: The microglial P2Y(6) receptor mediates neuronal loss and memory deficits in neurodegeneration.
Inflammatory neuronal loss in the substantia nigra induced by systemic lipopolysaccharide is prevented by knockout of the P2Y6 receptor in mice.
Title: Inflammatory neuronal loss in the substantia nigra induced by systemic lipopolysaccharide is prevented by knockout of the P2Y(6) receptor in mice.
The UDP/P2y6 axis promotes lung metastasis of melanoma by remodeling the premetastatic niche.
Title: The UDP/P2y6 axis promotes lung metastasis of melanoma by remodeling the premetastatic niche.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled ADP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled ADP receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled ADP receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled UDP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled UDP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled UDP receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled UTP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled UTP receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled UTP receptor activity	ISO Inferred from Sequence Orthology more info
enables pyrimidine nucleotide binding	IC Inferred by Curator more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to prostaglandin E stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to purine-containing compound	IEA Inferred from Electronic Annotation more info
involved_in cellular response to purine-containing compound	ISO Inferred from Sequence Orthology more info
involved_in cellular response to pyrimidine ribonucleotide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to pyrimidine ribonucleotide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to pyrimidine ribonucleotide	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inositol trisphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inositol trisphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transepithelial chloride transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: P2Y purinoceptor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183168.2 → NP_898991.1 P2Y purinoceptor 6

See identical proteins and their annotated locations for NP_898991.1

Status: VALIDATED

Source sequence(s)

AC151414

Consensus CDS

CCDS21507.1

UniProtKB/Swiss-Prot

Q9ERK9

UniProtKB/TrEMBL

Q3UQ86

Related

ENSMUSP00000055697.5, ENSMUST00000060174.6

Conserved Domains (2) summary

cd14964
Location:27 → 54

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 312

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

100586837..100628528 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152995.1 → XP_036008888.1 P2Y purinoceptor 6 isoform X1

UniProtKB/Swiss-Prot

Q9ERK9

UniProtKB/TrEMBL

Q3UQ86

Conserved Domains (2) summary

cd14964
Location:27 → 54

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 312

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_011241739.4 → XP_011240041.1 P2Y purinoceptor 6 isoform X1

See identical proteins and their annotated locations for XP_011240041.1

UniProtKB/Swiss-Prot

Q9ERK9

UniProtKB/TrEMBL

Q3UQ86

Conserved Domains (2) summary

cd14964
Location:27 → 54

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 312

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006507640.4 → XP_006507703.1 P2Y purinoceptor 6 isoform X1

See identical proteins and their annotated locations for XP_006507703.1

UniProtKB/Swiss-Prot

Q9ERK9

UniProtKB/TrEMBL

Q3UQ86

Conserved Domains (2) summary

cd14964
Location:27 → 54

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 312

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily