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    Klhl26 kelch-like 26 [ Mus musculus (house mouse) ]

    Gene ID: 234378, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klhl26provided by MGI
    Official Full Name
    kelch-like 26provided by MGI
    Primary source
    MGI:MGI:2443079
    See related
    Ensembl:ENSMUSG00000055707 AllianceGenome:MGI:2443079
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Klkl26; C630013N10Rik
    Summary
    Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human KLHL26 (kelch like family member 26). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 51.8), adrenal adult (RPKM 47.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klhl26 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70902868..70929660, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70450218..70476989, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51533 Neighboring gene cartilage oligomeric matrix protein Neighboring gene CREB regulated transcription coactivator 1 Neighboring gene STARR-positive B cell enhancer ABC_E1368 Neighboring gene RIKEN cDNA 1700020G03 gene Neighboring gene transmembrane protein 59-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Homology

    Clone Names

    • MGC38024

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122830.1 → NP_001116302.1  kelch-like protein 26 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 2.
      Source sequence(s)
      AK048601, AW495342, BY230115
      Consensus CDS
      CCDS52573.1
      UniProtKB/TrEMBL
      E9Q4C1
      Related
      ENSMUSP00000129607.2, ENSMUST00000166976.3
      Conserved Domains (5) summary
      smart00612
      Location:439 → 485
      Kelch; Kelch domain
      sd00038
      Location:282 → 329
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:19 → 87
      BTB; BTB/POZ domain
      pfam01344
      Location:333 → 370
      Kelch_1; Kelch motif
      pfam07707
      Location:95 → 196
      BACK; BTB And C-terminal Kelch

    2. NM_001364258.1 → NP_001351187.1  kelch-like protein 26 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC157774, AC158553
      Consensus CDS
      CCDS90410.1
      Related
      ENSMUSP00000147349.2, ENSMUST00000209567.2
      Conserved Domains (4) summary
      PHA03098
      Location:27 → 507
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:262 → 309
      Kelch; KELCH repeat [structural motif]
      cl38908
      Location:1 → 75
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl28903
      Location:70 → 166
      BACK; BACK (BTB and C-terminal Kelch) domain

    3. NM_178771.3 → NP_848886.1  kelch-like protein 26 isoform 2

      See identical proteins and their annotated locations for NP_848886.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AK049946
      Consensus CDS
      CCDS40373.1
      UniProtKB/Swiss-Prot
      Q8BGY4, Q8CIG6, Q8R153
      Related
      ENSMUSP00000069077.6, ENSMUST00000066597.13
      Conserved Domains (4) summary
      PHA03098
      Location:56 → 588
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:343 → 390
      Kelch; KELCH repeat [structural motif]
      cd18255
      Location:36 → 156
      BTB_POZ_KLHL26; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26)
      cl28903
      Location:151 → 247
      BACK; BACK (BTB and C-terminal Kelch) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70902868..70929660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243486.2 → XP_030099346.1  kelch-like protein 26 isoform X2

      Conserved Domains (2) summary
      PHA03098
      Location:100 → 342
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:97 → 144
      Kelch; KELCH repeat [structural motif]

    2. XM_006509654.5 → XP_006509717.1  kelch-like protein 26 isoform X1

      See identical proteins and their annotated locations for XP_006509717.1

      UniProtKB/Swiss-Prot
      Q8BGY4
      Conserved Domains (4) summary
      PHA03098
      Location:27 → 507
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:262 → 309
      Kelch; KELCH repeat [structural motif]
      cl38908
      Location:1 → 75
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl28903
      Location:70 → 166
      BACK; BACK (BTB and C-terminal Kelch) domain

    3. XM_030243484.2 → XP_030099344.1  kelch-like protein 26 isoform X2

      Conserved Domains (2) summary
      PHA03098
      Location:100 → 342
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:97 → 144
      Kelch; KELCH repeat [structural motif]

    4. XM_030243483.2 → XP_030099343.1  kelch-like protein 26 isoform X1

      Conserved Domains (4) summary
      PHA03098
      Location:27 → 507
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:262 → 309
      Kelch; KELCH repeat [structural motif]
      cl38908
      Location:1 → 75
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl28903
      Location:70 → 166
      BACK; BACK (BTB and C-terminal Kelch) domain

    5. XM_030243487.1 → XP_030099347.1  kelch-like protein 26 isoform X2

      Conserved Domains (2) summary
      PHA03098
      Location:100 → 342
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:97 → 144
      Kelch; KELCH repeat [structural motif]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172052.1: Suppressed sequence

      Description
      NM_172052.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGY4.1 GenPept UniProtKB/Swiss-Prot:Q8BGY4

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