Guf1 GTP binding elongation factor GUF1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Guf1provided by RGD
Official Full Name: GTP binding elongation factor GUF1provided by RGD
Primary source: RGD:1310774
See related: EnsemblRapid:ENSRNOG00000002207 AllianceGenome:RGD:1310774
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310774
Summary: Predicted to enable mitochondrial ribosome binding activity. Predicted to be involved in positive regulation of translation. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 40. Orthologous to human GUF1 (GTP binding elongation factor GUF1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 97.1), Muscle (RPKM 87.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (38891905..38911283, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (38537953..38557331, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (62609484..62628862)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Guf1 overexpression improves pancreatic beta cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery.
Title: Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery.

Submit: New GeneRIF Correction

General gene information

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Markers

RH129612 (e-PCR)
- UniSTS:212910

RH142376 (e-PCR)
- UniSTS:231623

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables mitochondrial ribosome binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: translation factor GUF1, mitochondrial

Names: GTP-binding protein GUF1 homolog; GUF1 GTPase homolog; GUF1 homolog, GTPase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107215.1 → NP_001100685.1 translation factor GUF1, mitochondrial

See identical proteins and their annotated locations for NP_001100685.1

Status: PROVISIONAL

Source sequence(s)

CH473981

UniProtKB/TrEMBL

A6JD91, D3ZHF8

Related

ENSRNOP00000003017.5, ENSRNOT00000003017.7

Conserved Domains (6) summary

cd01890
Location:59 → 236

LepA; LepA also known as Elongation Factor 4 (EF4)

PRK05433
Location:49 → 655

PRK05433; GTP-binding protein LepA; Provisional

cd03709
Location:461 → 540

lepA_C; lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits ...

pfam06421
Location:548 → 654

LepA_C; GTP-binding protein LepA C-terminus

cd03699
Location:244 → 329

EF4_II; Domain II of Elongation Factor 4 (EF4)

cd16260
Location:345 → 420

EF4_III; Domain III of Elongation Factor 4 (EF4)