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    Zfyve19 zinc finger FYVE-type containing 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499871, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfyve19provided by RGD
    Official Full Name
    zinc finger FYVE-type containing 19provided by RGD
    Primary source
    RGD:1561576
    See related
    EnsemblRapid:ENSRNOG00000012528 AllianceGenome:RGD:1561576
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in abscission; mitotic cytokinesis checkpoint signaling; and negative regulation of cytokinesis. Predicted to be active in centrosome; cleavage furrow; and midbody. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human ZFYVE19 (zinc finger FYVE-type containing 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 107.6), Lung (RPKM 77.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfyve19 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (126649625..126657812)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (106195779..106203969)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111013856..111021841)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene GTP cyclohydrolase I feedback regulator Neighboring gene similar to human chromosome 15 open reading frame 62 Neighboring gene DnaJ heat shock protein family (Hsp40) member C17 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14D Neighboring gene uncharacterized LOC134486140 Neighboring gene serine peptidase inhibitor, Kunitz type 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4. Thoresen SB, et al. Nat Cell Biol, 2014 Jun. PMID 24814515
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124714

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in abscission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in midbody abscission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in midbody abscission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cytokinesis checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    abscission/NoCut checkpoint regulator
    Names
    zinc finger FYVE domain-containing protein 19
    zinc finger, FYVE domain containing 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034948.1 → NP_001030120.1  abscission/NoCut checkpoint regulator

      See identical proteins and their annotated locations for NP_001030120.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099795
      UniProtKB/TrEMBL
      A0A8J8Y9Q4, F1LQM4, Q499R6
      Related
      ENSRNOP00000095388.2, ENSRNOT00000097300.2
      Conserved Domains (1) summary
      cd15749
      Location:4 → 54
      FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      126649625..126657812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105681.2 → XP_038961609.1  abscission/NoCut checkpoint regulator isoform X1

      UniProtKB/TrEMBL
      A0A8J8Y9Q4
      Conserved Domains (2) summary
      cd15749
      Location:4 → 54
      FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
      cd19817
      Location:340 → 384
      Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins

    2. XM_039105683.2 → XP_038961611.1  abscission/NoCut checkpoint regulator isoform X3

      UniProtKB/TrEMBL
      A0A8J8Y9Q4
      Related
      ENSRNOP00000016854.6, ENSRNOT00000016854.7
      Conserved Domains (2) summary
      cd15749
      Location:4 → 54
      FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
      cd19817
      Location:334 → 378
      Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins

    3. XM_039105682.2 → XP_038961610.1  abscission/NoCut checkpoint regulator isoform X2

      UniProtKB/TrEMBL
      A0A8J8Y9Q4
      Related
      ENSRNOP00000100004.1, ENSRNOT00000133359.1
      Conserved Domains (2) summary
      cd15749
      Location:4 → 54
      FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
      cd19817
      Location:339 → 383
      Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins

    4. XM_039105685.2 → XP_038961613.1  abscission/NoCut checkpoint regulator isoform X4

      Conserved Domains (1) summary
      cd19817
      Location:196 → 240
      Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins

    5. XM_063284365.1 → XP_063140435.1  abscission/NoCut checkpoint regulator isoform X5

    6. XM_039105686.2 → XP_038961614.1  abscission/NoCut checkpoint regulator isoform X4

      Conserved Domains (1) summary
      cd19817
      Location:196 → 240
      Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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