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    Robo3 roundabout guidance receptor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315564, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Robo3provided by RGD
    Official Full Name
    roundabout guidance receptor 3provided by RGD
    Primary source
    RGD:1311018
    See related
    EnsemblRapid:ENSRNOG00000030016 AllianceGenome:RGD:1311018
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in positive regulation of axon guidance. Predicted to be located in axon. Predicted to be active in neuron projection. Orthologous to human ROBO3 (roundabout guidance receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 11.0), Kidney (RPKM 4.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Robo3 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (45322323..45340466, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (37133542..37151674, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (39892792..39923735, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 15 Neighboring gene transfer RNA proline (anticodon AGG) 64 Neighboring gene uncharacterized LOC120094115 Neighboring gene hepatic and glial cell adhesion molecule Neighboring gene roundabout guidance receptor 4 Neighboring gene uncharacterized LOC102549473 Neighboring gene Myb/SANT DNA binding domain containing 2 Neighboring gene endothelial cell adhesion molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Robo3.1A suppresses slit-mediated repulsion by triggering degradation of Robo2. Li L, et al. J Neurosci Res, 2014 Jul. PMID 24936616
    2. Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells. García M, et al. Biochim Biophys Acta, 2009 Nov. PMID 19747951
    3. Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion. Chen Z, et al. Neuron, 2008 May 8. PMID 18466743
    4. Expression of netrin-1, slit-1 and slit-3 but not of slit-2 after cerebellar and spinal cord lesions. Wehrle R, et al. Eur J Neurosci, 2005 Nov. PMID 16262652
    5. The slit receptor Rig-1/Robo3 controls midline crossing by hindbrain precerebellar neurons and axons. Marillat V, et al. Neuron, 2004 Jul 8. PMID 15233918

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Visfatin through STAT3 activation enhances IL-6 expression that promotes endothelial angiogenesis.
      Title: Regulation and function of the cytosolic viral RNA sensor RIG-I in pancreatic beta cells.
    2. Data show that cerebellofugal axons express Rig-1 (Robo3) before they reach the midline but not after the longitudinal turn.
      Title: Crucial roles of Robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axon midline choice point recognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in commissural neuron axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in commissural neuron axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    roundabout homolog 3
    Names
    roundabout, axon guidance receptor, homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394075.1 → NP_001381004.1  roundabout homolog 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AJI9, A6KRL2, D3ZKA2
      Related
      ENSRNOP00000094407.1, ENSRNOT00000118811.2
      Conserved Domains (5) summary
      smart00408
      Location:465 → 528
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:264 → 343
      IG; Immunoglobulin
      smart00410
      Location:172 → 254
      IG_like; Immunoglobulin like
      cd00063
      Location:556 → 649
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:450 → 454
      Ig; Ig strand A [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      45322323..45340466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265426.1 → XP_063121496.1  roundabout homolog 3 isoform X1

      UniProtKB/TrEMBL
      A6KRL2, D3ZKA2

    2. XM_017595621.3 → XP_017451110.2  roundabout homolog 3 isoform X2

      UniProtKB/TrEMBL
      A6KRL2, D3ZKA2
      Conserved Domains (3) summary
      cd00063
      Location:556 → 649
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:348 → 352
      Ig; Ig strand A [structural motif]
      cl11960
      Location:348 → 445
      Ig; Immunoglobulin domain

    3. XM_063265427.1 → XP_063121497.1  roundabout homolog 3 isoform X3

    4. XM_063265428.1 → XP_063121498.1  roundabout homolog 3 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108135.1: Suppressed sequence

      Description
      NM_001108135.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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