Cnih3 cornichon family AMPA receptor auxiliary protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnih3provided by MGI
Official Full Name: cornichon family AMPA receptor auxiliary protein 3provided by MGI
Primary source: MGI:MGI:1920228
See related: Ensembl:ENSMUSG00000026514 AllianceGenome:MGI:1920228
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CNIH-3; 2900075G08Rik
Summary: Predicted to enable channel regulator activity and signaling receptor binding activity. Involved in neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human CNIH3 (cornichon family AMPA receptor auxiliary protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in frontal lobe adult (RPKM 13.2), cortex adult (RPKM 12.3) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 84.53 cM; 1 H4

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (181178024..181288059)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (181350459..181460641)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cnih3 Deletion Dysregulates Dorsal Hippocampal Transcription across the Estrous Cycle.
Title: Cnih3 Deletion Dysregulates Dorsal Hippocampal Transcription across the Estrous Cycle.
Study's convergent findings in humans and mice support CNIH3 involvement in the pathophysiology of opioid dependence, complementing prior studies implicating the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate system
Title: Evidence of CNIH3 involvement in opioid dependence.
In cornichon-3 and cornichon-2 knockout mice there is a profound reduction of AMPA receptor synaptic transmission in the hippocampus.
Title: Cornichon proteins determine the subunit composition of synaptic AMPA receptors.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234293

Cnih3 (e-PCR), detects polymorphism
- UniSTS:506807

NoName (e-PCR)
- UniSTS:493242

MHAa88e6.seq (e-PCR)
- UniSTS:125435

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables channel regulator activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within localization within membrane	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of AMPA receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of AMPA receptor activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	ISO Inferred from Sequence Orthology more info
part_of AMPA glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein cornichon homolog 3

Names: cornichon homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001160211.2 → NP_001153683.1 protein cornichon homolog 3 isoform 2

See identical proteins and their annotated locations for NP_001153683.1

Status: VALIDATED

Source sequence(s)

AC113084, AC119235

Consensus CDS

CCDS48470.1

UniProtKB/Swiss-Prot

Q14BS0, Q6ZWS4

Related

ENSMUSP00000027795.8, ENSMUST00000027795.14

Conserved Domains (1) summary

pfam03311
Location:7 → 151

Cornichon; Cornichon protein
NM_001160212.2 → NP_001153684.1 protein cornichon homolog 3 isoform 3

See identical proteins and their annotated locations for NP_001153684.1

Status: VALIDATED

Source sequence(s)

AC113084, AC119235

Consensus CDS

CCDS48471.1

UniProtKB/TrEMBL

G3XA11

Related

ENSMUSP00000124247.2, ENSMUST00000162685.2

Conserved Domains (1) summary

pfam03311
Location:7 → 106

Cornichon; Cornichon protein
NM_028408.4 → NP_082684.1 protein cornichon homolog 3 isoform 1

See identical proteins and their annotated locations for NP_082684.1

Status: VALIDATED

Source sequence(s)

AC113084, AC119235

Consensus CDS

CCDS35810.1

UniProtKB/TrEMBL

Q9D6E1

Related

ENSMUSP00000124611.2, ENSMUST00000161880.8

Conserved Domains (1) summary

pfam03311
Location:7 → 170

Cornichon; Cornichon protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

181178024..181288059

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243142.1 → XP_030099002.1 protein cornichon homolog 3 isoform X1

UniProtKB/TrEMBL

A0A1B0GSP1

Related

ENSMUSP00000148015.2, ENSMUST00000209607.2

Conserved Domains (1) summary

pfam03311
Location:8 → 178

Cornichon; Cornichon protein
XM_006496989.5 → XP_006497052.1 protein cornichon homolog 3 isoform X2

Conserved Domains (1) summary

pfam03311
Location:8 → 125

Cornichon; Cornichon protein