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    Mapk13 mitogen-activated protein kinase 13 [ Mus musculus (house mouse) ]

    Gene ID: 26415, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mapk13provided by MGI
    Official Full Name
    mitogen-activated protein kinase 13provided by MGI
    Primary source
    MGI:MGI:1346864
    See related
    Ensembl:ENSMUSG00000004864 AllianceGenome:MGI:1346864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SAPK4; Serk4
    Summary
    Predicted to enable ATP binding activity and MAP kinase activity. Predicted to be involved in several processes, including cellular response to anisomycin; cellular response to sodium arsenite; and cellular response to sorbitol. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; respiratory system; and sensory organ. Orthologous to human MAPK13 (mitogen-activated protein kinase 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 152.1), colon adult (RPKM 106.2) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mapk13 in Genome Data Viewer
    Location:
    17 A3.3; 17 15.0 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28988260..28997678)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28769286..28778704)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42228 Neighboring gene solute carrier family 26, member 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28828272-28828381 Neighboring gene mitogen-activated protein kinase 14 Neighboring gene G protein subunit gamma 5C Neighboring gene STARR-seq mESC enhancer starr_42232 Neighboring gene STARR-seq mESC enhancer starr_42233 Neighboring gene STARR-positive B cell enhancer ABC_E167 Neighboring gene predicted gene, 35883 Neighboring gene bromodomain and PHD finger containing, 3 Neighboring gene patatin-like phospholipase domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E11634 Neighboring gene STARR-seq mESC enhancer starr_42238

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables JUN kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to anisomycin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to anisomycin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interleukin-1 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to sodium arsenite IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to sodium arsenite ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to sorbitol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to sorbitol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to osmotic stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress-activated MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    mitogen-activated protein kinase 13
    Names
    MAP kinase 13
    MAP kinase p38 delta
    MAPK 13
    SAPK/Erk/kinase 4
    mitogen-activated protein kinase p38 delta
    p38 delta MAP kinase
    stress-activated protein kinase 4
    NP_036080.2
    XP_017172968.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011950.2NP_036080.2  mitogen-activated protein kinase 13

      See identical proteins and their annotated locations for NP_036080.2

      Status: VALIDATED

      Source sequence(s)
      AK146993, CJ182359, U81823
      Consensus CDS
      CCDS28584.1
      UniProtKB/Swiss-Prot
      Q99M57, Q9Z1B7
      UniProtKB/TrEMBL
      A0A3F2YNL4, Q3UIB2
      Related
      ENSMUSP00000156387.2, ENSMUST00000233984.2
      Conserved Domains (2) summary
      cd07879
      Location:9351
      STKc_p38delta; Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase (also called MAPK13)
      smart00220
      Location:30308
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      28988260..28997678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317479.2XP_017172968.1  mitogen-activated protein kinase 13 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1273
      PKc_like; Protein Kinases, catalytic domain