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    Skor2 SKI family transcriptional corepressor 2 [ Mus musculus (house mouse) ]

    Gene ID: 664805, updated on 9-Dec-2024

    Summary

    Official Symbol
    Skor2provided by MGI
    Official Full Name
    SKI family transcriptional corepressor 2provided by MGI
    Primary source
    MGI:MGI:3645984
    See related
    Ensembl:ENSMUSG00000091519 AllianceGenome:MGI:3645984
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Corl2; Gm7348; EG664805; Fussel18
    Summary
    Enables SMAD binding activity; chromatin binding activity; and histone deacetylase binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cerebellar Purkinje cell differentiation; regulation of neural precursor cell proliferation; and regulation of signal transduction. Located in nucleus. Is expressed in brain; dorsal root ganglion; and spinal cord. Orthologous to human SKOR2 (SKI family transcriptional corepressor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 1.6), whole brain E14.5 (RPKM 1.5) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Skor2 in Genome Data Viewer
    Location:
    18 E3; 18 51.93 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (76934428..76988759)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (76846733..76901064)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31933 Neighboring gene C2 calcium-dependent domain containing 2-like pseudogene Neighboring gene STARR-seq mESC enhancer starr_45102 Neighboring gene STARR-seq mESC enhancer starr_45103 Neighboring gene predicted gene, 32058 Neighboring gene immediate early response 3 interacting protein 1 Neighboring gene predicted gene, 53183

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebellar Purkinje cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebellum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cerebellar granule cell precursor proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    SKI family transcriptional corepressor 2
    Names
    LBX1 corepressor 1-like protein
    functional Smad suppressor element on chromosome 18
    fussel-18 homolog
    ladybird homeobox corepressor 1-like protein
    transcriptional corepressor Corl2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109743.1NP_001103213.1  SKI family transcriptional corepressor 2

      See identical proteins and their annotated locations for NP_001103213.1

      Status: PROVISIONAL

      Source sequence(s)
      AB358976
      Consensus CDS
      CCDS50322.1
      UniProtKB/Swiss-Prot
      A7M7C7
      Related
      ENSMUSP00000132338.2, ENSMUST00000166956.2
      Conserved Domains (2) summary
      pfam02437
      Location:39132
      Ski_Sno; SKI/SNO/DAC family
      pfam08782
      Location:145235
      c-SKI_SMAD_bind; c-SKI Smad4 binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      76934428..76988759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526436.3XP_006526499.1  SKI family transcriptional corepressor 2 isoform X1

      See identical proteins and their annotated locations for XP_006526499.1

      UniProtKB/Swiss-Prot
      A7M7C7
      Conserved Domains (2) summary
      pfam02437
      Location:39132
      Ski_Sno; SKI/SNO/DAC family
      pfam08782
      Location:145235
      c-SKI_SMAD_bind; c-SKI Smad4 binding domain