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    Dusp5 dual specificity phosphatase 5 [ Mus musculus (house mouse) ]

    Gene ID: 240672, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dusp5provided by MGI
    Official Full Name
    dual specificity phosphatase 5provided by MGI
    Primary source
    MGI:MGI:2685183
    See related
    Ensembl:ENSMUSG00000034765 AllianceGenome:MGI:2685183
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm337
    Summary
    Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Predicted to be involved in several processes, including endoderm formation; protein dephosphorylation; and regulation of blood circulation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cerebellum; lung; retina layer; and telencephalon mantle layer. Orthologous to human DUSP5 (dual specificity phosphatase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thymus adult (RPKM 25.5), duodenum adult (RPKM 24.5) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Dusp5 in Genome Data Viewer
    Location:
    19 D2; 19 47.98 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (53517576..53530240)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (53529145..53541809)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene myocardial infarction associated transcript 1 Neighboring gene RIKEN cDNA 4833407H14 gene Neighboring gene STARR-seq mESC enhancer starr_46456 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:53539230-53539416 Neighboring gene predicted gene, 30826 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:53577410-53577623 Neighboring gene STARR-positive B cell enhancer mm9_chr19:53603336-53603637 Neighboring gene predicted gene, 54049 Neighboring gene nuclear transport factor 2, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine/serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoderm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-threonine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cerebral blood circulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    dual specificity protein phosphatase 5
    NP_001078859.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085390.2NP_001078859.1  dual specificity protein phosphatase 5

      See identical proteins and their annotated locations for NP_001078859.1

      Status: VALIDATED

      Source sequence(s)
      AC137853
      Consensus CDS
      CCDS38024.1
      UniProtKB/TrEMBL
      Q1HL35
      Related
      ENSMUSP00000047900.7, ENSMUST00000038287.7
      Conserved Domains (3) summary
      COG2453
      Location:227318
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      cd00127
      Location:178314
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:5140
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      53517576..53530240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)