Frzb frizzled-related protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Frzbprovided by MGI
Official Full Name: frizzled-related proteinprovided by MGI
Primary source: MGI:MGI:892032
See related: Ensembl:ENSMUSG00000027004 AllianceGenome:MGI:892032
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Frp; Sfrp3; fritz; frzb-1; frezzled
Summary: Enables Wnt-protein binding activity. Involved in negative regulation of Wnt signaling pathway; neural crest cell differentiation; and somite development. Acts upstream of or within several processes, including cochlea morphogenesis; negative regulation of canonical Wnt signaling pathway; and negative regulation of cell differentiation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human FRZB (frizzled related protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in adrenal adult (RPKM 171.5) and frontal lobe adult (RPKM 11.7) See more
Orthologs: human all
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Genomic context

Location:: 2 C3; 2 48.13 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (80242314..80277740, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (80411970..80447396, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Secreted frizzled-related protein 3 alleviated cardiac remodeling induced by angiotensin II via inhibiting oxidative stress and apoptosis in mice.
Title: Secreted frizzled-related protein 3 alleviated cardiac remodeling induced by angiotensin II via inhibiting oxidative stress and apoptosis in mice.
Secreted frizzled-related protein 3 was genetically and functionally associated with developmental dysplasia of the hip.
Title: Secreted frizzled-related protein 3 was genetically and functionally associated with developmental dysplasia of the hip.
Frizzled related protein deficiency impairs muscle strength, gait and calpain 3 levels.
Title: Frizzled related protein deficiency impairs muscle strength, gait and calpain 3 levels.
Study identifies Sfrp3 as a mediator of the stromal-epithelial communication that is required for normal mouse mammary gland development. Loss of Sfrp3 in mice leads to an increase of ductal invasion and branching mirroring an early pregnancy state and predisposes for invasive breast cancer.
Title: Sfrp3 modulates stromal-epithelial crosstalk during mammary gland development by regulating Wnt levels.
The results of this study suggested that Frzb secreted from olfactory ensheathing cells in the olfactory nerve layer is important for olfactory axon targeting.
Title: Olfactory ensheathing cells abutting the embryonic olfactory bulb express Frzb, whose deletion disrupts olfactory axon targeting.
particle-induced inhibition on cell proliferation, differentiation and FRZB expression were all reversed by miR-130b silence
Title: MicroRNA-130b Promotes Wear Particle-Induced Osteolysis via Downregulating Frizzled-Related Protein (FRZB).
Stable overexpression of Frzb in MC3T3-E1 cells increased calcium deposition and osteoblast markers compared with control. Western blot analysis showed that the increased osteogenesis was associated with reduced canonical, but increased non-canonical Wnt signaling.
Title: Osteogenesis induced by frizzled-related protein (FRZB) is linked to the netrin-like domain.
an inverse septal-to-temporal increase in the expression of sfrp3 that emerges during postnatal development, is reported.
Title: A septo-temporal molecular gradient of sfrp3 in the dentate gyrus differentially regulates quiescent adult hippocampal neural stem cell activation.
The spatiotemporally dynamic expression ofsFRP3 strongly suggests that sFRP3 has potential functions in the sensory neuron genesis and sensory circuitry formation.
Title: Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia.
Our results suggest that FrzB may have a protective role on cartilage degradation and matrix metalloproteinase induction in mouse chondrocytes
Title: Protective role of frizzled-related protein B on matrix metalloproteinase induction in mouse chondrocytes.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sfrp3 (e-PCR)
- UniSTS:144395

Frzb (e-PCR), detects polymorphism
- UniSTS:471830

Frzb (e-PCR), detects polymorphism
- UniSTS:506906

Frzb (e-PCR), detects polymorphism
- UniSTS:495986

Frzb (e-PCR), detects polymorphism
- UniSTS:474747

RH132687 (e-PCR)
- UniSTS:215970

U88568 (e-PCR)
- UniSTS:178647

Frzb (e-PCR), detects polymorphism
- UniSTS:547816

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IDA Inferred from Direct Assay more info	PubMed
enables Wnt-protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cochlea morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in organogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of epithelial cell development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of hepatocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cell development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of hepatocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in neural crest cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in somite development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: secreted frizzled-related protein 3

Names: frizzled-related protein 1; secreted frizzled-related sequence protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011356.4 → NP_035486.1 secreted frizzled-related protein 3 precursor

Status: VALIDATED

Source sequence(s)

AL928578

Consensus CDS

CCDS16176.1

UniProtKB/Swiss-Prot

O09075, O09093, P97401, Q91W58

Related

ENSMUSP00000028389.4, ENSMUST00000028389.4

Conserved Domains (2) summary

cd07441
Location:32 → 157

CRD_SFRP3; Cysteine-rich domain of the secreted frizzled-related protein 3 (SFRP3, alias FRZB), a Wnt antagonist

cd03581
Location:188 → 297

NTR_Sfrp3_like; NTR domain, Secreted frizzled-related protein (Sfrp) 3-like subfamily; composed of proteins similar to human Sfrp3 and Sfrp4. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse functions ...