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    Shank2 SH3 and multiple ankyrin repeat domains 2 [ Mus musculus (house mouse) ]

    Gene ID: 210274, updated on 9-Dec-2024

    Summary

    Official Symbol
    Shank2provided by MGI
    Official Full Name
    SH3 and multiple ankyrin repeat domains 2provided by MGI
    Primary source
    MGI:MGI:2671987
    See related
    Ensembl:ENSMUSG00000037541 AllianceGenome:MGI:2671987
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ProSAP1; mKIAA1022
    Summary
    Enables ionotropic glutamate receptor binding activity. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and social behavior. Located in several cellular components, including dendritic spine; photoreceptor inner segment; and photoreceptor outer segment. Colocalizes with neurofilament and postsynaptic membrane. Is expressed in cerebellum; cerebral cortex; frontal cortex; neocortex; and neocortex region. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human SHANK2 (SH3 and multiple ankyrin repeat domains 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 10.4), frontal lobe adult (RPKM 10.3) and 15 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Shank2 in Genome Data Viewer
    Location:
    7 F5; 7 88.45 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143531819..143979780)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143978077..144426043)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene microRNA 6404 Neighboring gene predicted gene, 34445 Neighboring gene microRNA 3105 Neighboring gene STARR-seq mESC enhancer starr_20539 Neighboring gene STARR-positive B cell enhancer mm9_chr7:151319991-151320291 Neighboring gene STARR-seq mESC enhancer starr_20542 Neighboring gene predicted gene 14372 Neighboring gene predicted gene, 34621 Neighboring gene predicted gene, 34561 Neighboring gene cortactin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (6)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1022

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ionotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adult behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in associative learning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term synaptic depression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in social behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vocalization behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vocalization behavior ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in asymmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ciliary membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in hippocampal mossy fiber to CA3 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with neurofilament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neurofilament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in photoreceptor inner segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in photoreceptor outer segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    SH3 and multiple ankyrin repeat domains protein 2
    Names
    SH3/ankyrin domain gene 2
    cortBP1
    cortactin-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081370.3NP_001074839.3  SH3 and multiple ankyrin repeat domains protein 2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate downstream promoter compared to variant 2 and encodes a shorter isoform (a) with a distinct N-terminus compared to isoform b.
      Source sequence(s)
      AC124520, AC140268
      Consensus CDS
      CCDS40201.1
      UniProtKB/TrEMBL
      A0A1C7ZMY3
      Related
      ENSMUSP00000146440.2, ENSMUST00000146006.3
    2. NM_001113373.3NP_001106844.3  SH3 and multiple ankyrin repeat domains protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (b).
      Source sequence(s)
      AC124520, AC140268, AC152166
      Consensus CDS
      CCDS85484.1
      UniProtKB/TrEMBL
      A0A6I8MWY3
      Related
      ENSMUSP00000101520.3, ENSMUST00000105900.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      143531819..143979780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508521.5XP_006508584.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006508584.1

      Conserved Domains (7) summary
      cd09506
      Location:18451910
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:586637
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164371
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:11291538
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:682774
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    2. XM_006508520.5XP_006508583.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006508583.1

      Conserved Domains (7) summary
      cd09506
      Location:18451910
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:586637
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164371
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:11291538
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:682774
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    3. XM_030242323.2XP_030098183.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X11

      Conserved Domains (7) summary
      cd09506
      Location:17881853
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:529580
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164406
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:10721481
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:625717
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    4. XM_030242322.2XP_030098182.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X11

      Conserved Domains (7) summary
      cd09506
      Location:17881853
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:529580
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164406
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:10721481
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:625717
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    5. XM_017322092.3XP_017177581.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X10

      Conserved Domains (6) summary
      cd09506
      Location:18271892
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:586637
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164371
      PHA03095; ankyrin-like protein; Provisional
      cd00992
      Location:682774
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    6. XM_017322091.3XP_017177580.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X9

      Conserved Domains (6) summary
      cd09506
      Location:18271892
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:586637
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164371
      PHA03095; ankyrin-like protein; Provisional
      cd00992
      Location:682774
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    7. XM_006508525.5XP_006508588.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X4

      Conserved Domains (7) summary
      cd09506
      Location:18381903
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:586637
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164371
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:11221531
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:682774
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    8. XM_006508526.5XP_006508589.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X5

      Conserved Domains (7) summary
      cd09506
      Location:18361901
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:586637
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164371
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:11201529
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:682774
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    9. XM_006508529.5XP_006508592.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X8

      Conserved Domains (7) summary
      cd09506
      Location:18291894
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:586637
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164371
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:11131522
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:682774
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    10. XM_006508519.5XP_006508582.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006508582.1

      Conserved Domains (7) summary
      cd09506
      Location:18451910
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:586637
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164371
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:11291538
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:682774
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    11. XM_006508524.5XP_006508587.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

      Conserved Domains (7) summary
      cd09506
      Location:18381903
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:586637
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164371
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:11221531
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:682774
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    12. XM_006508523.4XP_006508586.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X2

      Conserved Domains (7) summary
      cd09506
      Location:18411906
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:586637
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164371
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:11251534
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:682774
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    13. XM_006508527.4XP_006508590.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X6

      Conserved Domains (7) summary
      cd09506
      Location:18341899
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:586637
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164371
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:11181527
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:682774
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    14. XM_006508522.5XP_006508585.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006508585.1

      Conserved Domains (7) summary
      cd09506
      Location:18451910
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:586637
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164371
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:11291538
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:682774
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    15. XM_006508528.5XP_006508591.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X7

      Conserved Domains (7) summary
      cd09506
      Location:18311896
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:586637
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164371
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:11151524
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:682774
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    16. XM_006508530.5XP_006508593.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X11

      Conserved Domains (7) summary
      cd09506
      Location:17881853
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:529580
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164406
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:10721481
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:625717
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    17. XM_006508531.5XP_006508594.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X12

      Conserved Domains (7) summary
      cd09506
      Location:17841849
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:529580
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164406
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:10681477
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:625717
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    18. XM_006508532.5XP_006508595.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X13

      UniProtKB/TrEMBL
      D3Z5K8
      Related
      ENSMUSP00000101522.2, ENSMUST00000105902.8
      Conserved Domains (7) summary
      cd09506
      Location:17741839
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:529580
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03095
      Location:164406
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:10581467
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:625717
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      sd00045
      Location:230261
      ANK; ANK repeat [structural motif]
      cl28922
      Location:55142
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    19. XM_006508534.5XP_006508597.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X15

      UniProtKB/TrEMBL
      A0A6I8MWY3
      Conserved Domains (4) summary
      cd09506
      Location:14061471
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:147198
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03247
      Location:6901099
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:243335
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    20. XM_006508533.3XP_006508596.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X14

      See identical proteins and their annotated locations for XP_006508596.1

      UniProtKB/Swiss-Prot
      E9QPH7, Q3UTK4, Q5DU07, Q80Z38
      UniProtKB/TrEMBL
      A0A6I8MWY3
      Conserved Domains (4) summary
      cd09506
      Location:14091474
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:150201
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03247
      Location:6931102
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:246338
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    21. XM_030242325.2XP_030098185.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X16

      UniProtKB/TrEMBL
      A0A6I8MWY3
      Conserved Domains (4) summary
      cd09506
      Location:13951460
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      cd11983
      Location:150201
      SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
      PHA03247
      Location:6791088
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:246338
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    22. XM_006508535.4XP_006508598.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X17

      UniProtKB/TrEMBL
      A0A6I8MWY3
      Related
      ENSMUSP00000159313.2, ENSMUST00000239495.2
      Conserved Domains (3) summary
      cd09506
      Location:12181283
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03247
      Location:502911
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:55147
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    23. XM_036152869.1XP_036008762.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X22

      Conserved Domains (2) summary
      cd09506
      Location:914979
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03247
      Location:198607
      PHA03247; large tegument protein UL36; Provisional
    24. XM_030242327.1XP_030098187.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X19

      UniProtKB/TrEMBL
      A0A1C7ZMY3
      Conserved Domains (2) summary
      cd09506
      Location:10851150
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03247
      Location:369778
      PHA03247; large tegument protein UL36; Provisional
    25. XM_030242326.1XP_030098186.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X18

      UniProtKB/TrEMBL
      A0A1C7ZMY3
      Conserved Domains (3) summary
      cd09506
      Location:11781243
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03247
      Location:462871
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:36128
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    26. XM_006508536.4XP_006508599.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X19

      UniProtKB/TrEMBL
      A0A1C7ZMY3
      Conserved Domains (2) summary
      cd09506
      Location:10851150
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03247
      Location:369778
      PHA03247; large tegument protein UL36; Provisional
    27. XM_030242328.1XP_030098188.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X20

      UniProtKB/TrEMBL
      A0A1C7ZMY3
      Conserved Domains (2) summary
      cd09506
      Location:9611026
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03247
      Location:245654
      PHA03247; large tegument protein UL36; Provisional
    28. XM_030242329.1XP_030098189.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X21

      UniProtKB/TrEMBL
      A0A1C7ZMY3
      Conserved Domains (2) summary
      cd09506
      Location:9541019
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03247
      Location:238647
      PHA03247; large tegument protein UL36; Provisional
    29. XM_036152871.1XP_036008764.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X22

      Conserved Domains (2) summary
      cd09506
      Location:914979
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03247
      Location:198607
      PHA03247; large tegument protein UL36; Provisional
    30. XM_036152870.1XP_036008763.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X22

      Conserved Domains (2) summary
      cd09506
      Location:914979
      SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
      PHA03247
      Location:198607
      PHA03247; large tegument protein UL36; Provisional

    RNA

    1. XR_004934051.1 RNA Sequence

    2. XR_004934050.1 RNA Sequence