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    Nutf2 nuclear transport factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 68051, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nutf2provided by MGI
    Official Full Name
    nuclear transport factor 2provided by MGI
    Primary source
    MGI:MGI:1915301
    See related
    Ensembl:ENSMUSG00000008450 AllianceGenome:MGI:1915301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ntf2; Ntf3; PP15; 2700067I02Rik
    Summary
    Predicted to enable identical protein binding activity; nuclear import signal receptor activity; and small GTPase binding activity. Acts upstream of or within protein import into nucleus. Predicted to be located in cytosol; nuclear outer membrane; and nucleoplasm. Predicted to be part of nuclear pore central transport channel. Is expressed in several structures, including alimentary system; central nervous system; integumental system; salivary gland primordium; and sensory organ. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 42.8), CNS E14 (RPKM 34.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nutf2 in Genome Data Viewer
    Location:
    8 D3; 8 53.05 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106587165..106607034)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105860533..105880402)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene translin-associated factor X (Tsnax) interacting protein 1 Neighboring gene centromere protein T Neighboring gene STARR-positive B cell enhancer ABC_E2875 Neighboring gene STARR-positive B cell enhancer ABC_E3799 Neighboring gene THAP domain containing 11 Neighboring gene STARR-seq mESC enhancer starr_22544 Neighboring gene STARR-seq mESC enhancer starr_22545 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108404648-108404831 Neighboring gene enhancer of mRNA decapping 4 Neighboring gene neuritin 1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102015

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear import signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear import signal receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables nucleocytoplasmic carrier activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to nuclear pore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear pore central transport channel ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357229.1NP_001344158.1  nuclear transport factor 2

      Status: VALIDATED

      Source sequence(s)
      AC116569, AC159265
      Consensus CDS
      CCDS22617.1
      UniProtKB/Swiss-Prot
      P61971, Q3TI35
      UniProtKB/TrEMBL
      Q3U8H8
      Conserved Domains (1) summary
      cd00780
      Location:7122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    2. NM_001357230.1NP_001344159.1  nuclear transport factor 2

      Status: VALIDATED

      Source sequence(s)
      AC116569, AC159265
      Consensus CDS
      CCDS22617.1
      UniProtKB/Swiss-Prot
      P61971, Q3TI35
      UniProtKB/TrEMBL
      Q3U8H8
      Related
      ENSMUSP00000148713.2, ENSMUST00000212042.2
      Conserved Domains (1) summary
      cd00780
      Location:7122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    3. NM_026532.4NP_080808.1  nuclear transport factor 2

      See identical proteins and their annotated locations for NP_080808.1

      Status: VALIDATED

      Source sequence(s)
      AK002461, BC086773, CJ059612
      Consensus CDS
      CCDS22617.1
      UniProtKB/Swiss-Prot
      P61971, Q3TI35
      UniProtKB/TrEMBL
      Q3U8H8
      Related
      ENSMUSP00000008594.8, ENSMUST00000008594.9
      Conserved Domains (1) summary
      cd00780
      Location:7122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106587165..106607034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)