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    Ctrl chymotrypsin-like [ Mus musculus (house mouse) ]

    Gene ID: 109660, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ctrlprovided by MGI
    Official Full Name
    chymotrypsin-likeprovided by MGI
    Primary source
    MGI:MGI:88558
    See related
    Ensembl:ENSMUSG00000031896 AllianceGenome:MGI:88558
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ctra1; Ctra-1; mFLJ00366; chymopasin; 0910001G08Rik; 1810004D15Rik
    Summary
    Enables peptidase activity. Acts upstream of or within proteolysis. Is expressed in brain; embryo; pancreas; and pancreas tip epithelium. Orthologous to human CTRL (chymotrypsin like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in small intestine adult (RPKM 3550.0), spleen adult (RPKM 1859.9) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Ctrl in Genome Data Viewer
    Location:
    8 D3; 8 53.06 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106658626..106660494, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105931994..105933862, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene neuritin 1-like Neighboring gene STARR-positive B cell enhancer ABC_E3800 Neighboring gene protein serine kinase H1 Neighboring gene STARR-positive B cell enhancer ABC_E6679 Neighboring gene proteasome (prosome, macropain) subunit, beta type 10 Neighboring gene lecithin cholesterol acyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Clone Names

    • FLJ00366

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    chymotrypsin-like protease CTRL-1
    Names
    chymotrypsin A CTRA-1
    NP_075671.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023182.2NP_075671.1  chymotrypsin-like protease CTRL-1 precursor

      See identical proteins and their annotated locations for NP_075671.1

      Status: VALIDATED

      Source sequence(s)
      AB016228, CF582693
      Consensus CDS
      CCDS22620.1
      UniProtKB/TrEMBL
      Q9D7P8, Q9D960, Q9ER05
      Related
      ENSMUSP00000034368.7, ENSMUST00000034368.8
      Conserved Domains (2) summary
      smart00020
      Location:33257
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:34260
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106658626..106660494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)