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    Psmb10 proteasome (prosome, macropain) subunit, beta type 10 [ Mus musculus (house mouse) ]

    Gene ID: 19171, updated on 9-Dec-2024

    Summary

    Official Symbol
    Psmb10provided by MGI
    Official Full Name
    proteasome (prosome, macropain) subunit, beta type 10provided by MGI
    Primary source
    MGI:MGI:1096380
    See related
    Ensembl:ENSMUSG00000031897 AllianceGenome:MGI:1096380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mecl1; Mecl-1
    Summary
    Predicted to enable endopeptidase activity. Acts upstream of or within T cell proliferation and cell morphogenesis. Part of proteasome core complex and spermatoproteasome complex. Is expressed in several structures, including adrenal gland; cerebral cortex; genitourinary system; hemolymphoid system; and liver. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 5. Orthologous to human PSMB10 (proteasome 20S subunit beta 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in duodenum adult (RPKM 146.6), large intestine adult (RPKM 133.0) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Psmb10 in Genome Data Viewer
    Location:
    8 D3; 8 53.06 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106662360..106665024, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105935728..105938392, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3800 Neighboring gene protein serine kinase H1 Neighboring gene STARR-positive B cell enhancer ABC_E6679 Neighboring gene chymotrypsin-like Neighboring gene lecithin cholesterol acyltransferase Neighboring gene solute carrier family 12, member 4 Neighboring gene microRNA 7074

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables threonine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome core complex, beta-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of spermatoproteasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    proteasome subunit beta type-10
    Names
    low molecular mass protein 10
    macropain subunit MECl-1
    multicatalytic endopeptidase complex subunit MECl-1
    prosome Mecl1
    proteasome (prosomome, macropain) subunit, beta type 10
    proteasome MECl-1
    proteasome subunit MECL1
    proteasome subunit beta-2i
    NP_038668.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013640.3NP_038668.2  proteasome subunit beta type-10

      See identical proteins and their annotated locations for NP_038668.2

      Status: VALIDATED

      Source sequence(s)
      AC159265, BY686068, D85561
      Consensus CDS
      CCDS22621.1
      UniProtKB/Swiss-Prot
      O08687, O35955, Q99KC5
      UniProtKB/TrEMBL
      Q3UNP9, Q4FJX8
      Related
      ENSMUSP00000034369.9, ENSMUST00000034369.10
      Conserved Domains (3) summary
      TIGR03690
      Location:39238
      20S_bact_beta; proteasome, beta subunit, bacterial type
      cd03763
      Location:40226
      proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
      pfam12465
      Location:232267
      Pr_beta_C; Proteasome beta subunits C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106662360..106665024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)