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    Adamts18 ADAM metallopeptidase with thrombospondin type 1 motif 18 [ Mus musculus (house mouse) ]

    Gene ID: 208936, updated on 3-Dec-2024

    Summary

    Official Symbol
    Adamts18provided by MGI
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 18provided by MGI
    Primary source
    MGI:MGI:2442600
    See related
    Ensembl:ENSMUSG00000053399 AllianceGenome:MGI:2442600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ADAMTS21; 9630038L21; E130314N14Rik
    Summary
    Predicted to enable metalloendopeptidase activity. Acts upstream of or within negative regulation of platelet aggregation. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in several structures, including alimentary system; brain; eye; lung; and male reproductive gland or organ. Orthologous to human ADAMTS18 (ADAM metallopeptidase with thrombospondin type 1 motif 18). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E14 (RPKM 1.9), CNS E18 (RPKM 1.8) and 12 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Adamts18 in Genome Data Viewer
    Location:
    8 E1; 8 59.65 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (114423755..114575975, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (113697123..113849343, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene MON1 homolog B, secretory traffciking associated Neighboring gene synaptonemal complex central element protein 1 like Neighboring gene predicted gene, 30052 Neighboring gene STARR-seq mESC enhancer starr_22763 Neighboring gene predicted gene, 30107 Neighboring gene STARR-seq mESC enhancer starr_22765 Neighboring gene STARR-positive B cell enhancer ABC_E9028 Neighboring gene nudix hydrolase 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (7)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in eye development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in eye development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 18
    Names
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403922.1NP_001390851.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC108856, AC125463
      UniProtKB/TrEMBL
      B7ZMV1
    2. NM_001403923.1NP_001390852.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC108856, AC125463
      UniProtKB/TrEMBL
      Q8BKA1
    3. NM_001403924.1NP_001390853.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC108856, AC125463
      UniProtKB/TrEMBL
      Q8BKA1
    4. NM_172466.4NP_766054.2  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform a precursor

      See identical proteins and their annotated locations for NP_766054.2

      Status: VALIDATED

      Source sequence(s)
      AC108856, AC125463
      Consensus CDS
      CCDS40485.1
      UniProtKB/Swiss-Prot
      E9QNK0, Q4VC17, Q8BZD1
      UniProtKB/TrEMBL
      B7ZMV1
      Related
      ENSMUSP00000090801.5, ENSMUST00000093113.5
      Conserved Domains (7) summary
      smart00209
      Location:592644
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:293494
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:749861
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:65203
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08686
      Location:11861216
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:511578
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:935991
      TSP1_ADAMTS; Thrombospondin type 1 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      114423755..114575975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530797.2XP_006530860.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X3

      See identical proteins and their annotated locations for XP_006530860.1

      UniProtKB/TrEMBL
      B7ZMV1
      Conserved Domains (6) summary
      smart00209
      Location:512564
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:213414
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:80123
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:669781
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:11061136
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:431498
      ADAM_CR_2; ADAM cysteine-rich domain
    2. XM_006530795.4XP_006530858.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X1

      UniProtKB/TrEMBL
      B7ZMV1
      Conserved Domains (6) summary
      smart00209
      Location:626678
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:327528
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:99237
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:783895
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:12201250
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:545612
      ADAM_CR_2; ADAM cysteine-rich domain
    3. XM_030243369.1XP_030099229.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X5

      Conserved Domains (5) summary
      smart00209
      Location:180232
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:337449
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:774804
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:99166
      ADAM_CR_2; ADAM cysteine-rich domain
      cl00064
      Location:182
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
    4. XM_030243370.1XP_030099230.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X5

      Conserved Domains (5) summary
      smart00209
      Location:180232
      TSP1; Thrombospondin type 1 repeats
      pfam05986
      Location:337449
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:774804
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:99166
      ADAM_CR_2; ADAM cysteine-rich domain
      cl00064
      Location:182
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
    5. XM_017312629.2XP_017168118.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X2

      UniProtKB/TrEMBL
      B7ZMV1
      Conserved Domains (6) summary
      smart00209
      Location:548600
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:249450
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:116159
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:705817
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:11421172
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:467534
      ADAM_CR_2; ADAM cysteine-rich domain
    6. XM_006530801.4XP_006530864.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X4

      See identical proteins and their annotated locations for XP_006530864.1

      UniProtKB/TrEMBL
      Q8BKA1
      Conserved Domains (5) summary
      smart00209
      Location:420472
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:121322
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:577689
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:10141044
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:339406
      ADAM_CR_2; ADAM cysteine-rich domain
    7. XM_017312631.2XP_017168120.1  A disintegrin and metalloproteinase with thrombospondin motifs 18 isoform X6

      Conserved Domains (4) summary
      smart00209
      Location:626678
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:327528
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:99237
      Pep_M12B_propep; Reprolysin family propeptide
      pfam17771
      Location:545612
      ADAM_CR_2; ADAM cysteine-rich domain

    RNA

    1. XR_001778416.2 RNA Sequence

    2. XR_004934786.1 RNA Sequence

    3. XR_878788.3 RNA Sequence

    4. XR_001778415.2 RNA Sequence

    5. XR_004934785.1 RNA Sequence