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    Prss44 serine protease 44 [ Mus musculus (house mouse) ]

    Gene ID: 73336, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prss44provided by MGI
    Official Full Name
    serine protease 44provided by MGI
    Primary source
    MGI:MGI:1920586
    See related
    Ensembl:ENSMUSG00000032493 AllianceGenome:MGI:1920586
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    79H19A; Tessp4; TESSP-4; 1700036D21Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in germ cell development; proteolysis; and spermatogenesis. Located in cytoplasm. Orthologous to human PRSS44P (serine protease 44, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 10.8) See more
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    Genomic context

    See Prss44 in Genome Data Viewer
    Location:
    9 F2; 9 60.79 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110642987..110647067)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110813919..110817999)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46141 Neighboring gene serine protease 42 Neighboring gene serine protease 43 Neighboring gene serine protease 45

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity  
    enables serine-type endopeptidase activity  
    Process Evidence Code Pubs
    involved_in germ cell development  
    involved_in proteolysis  
    involved_in proteolysis  
    involved_in spermatogenesis  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in extracellular space  
    located_in membrane  

    General protein information

    Preferred Names
    serine protease 44
    Names
    protease, serine 44
    serine protease-like 1
    testis serine protease 4
    testis specific serine protease 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_148940.3NP_683742.2  serine protease 44 precursor

      See identical proteins and their annotated locations for NP_683742.2

      Status: VALIDATED

      Source sequence(s)
      AB162857, AK006612, AU043597
      Consensus CDS
      CCDS40782.1
      UniProtKB/Swiss-Prot
      Q402U7, Q924U6
      Related
      ENSMUSP00000095948.3, ENSMUST00000098345.3
      Conserved Domains (2) summary
      smart00020
      Location:111340
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:112340
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      110642987..110647067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512313.3XP_006512376.1  serine protease 44 isoform X1

      Conserved Domains (1) summary
      cd00190
      Location:11239
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_006512314.4XP_006512377.1  serine protease 44 isoform X2

      Conserved Domains (1) summary
      cd00190
      Location:112245
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. XM_017313617.2XP_017169106.1  serine protease 44 isoform X3

      Conserved Domains (1) summary
      cd00190
      Location:112245
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    4. XM_006512317.1XP_006512380.1  serine protease 44 isoform X4

      See identical proteins and their annotated locations for XP_006512380.1

      Conserved Domains (1) summary
      cd00190
      Location:12177
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    5. XM_030244649.1XP_030100509.1  serine protease 44 isoform X4

      Conserved Domains (1) summary
      cd00190
      Location:12177
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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