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    Lrrc2 leucine rich repeat containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 74249, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lrrc2provided by MGI
    Official Full Name
    leucine rich repeat containing 2provided by MGI
    Primary source
    MGI:MGI:1921499
    See related
    Ensembl:ENSMUSG00000032495 AllianceGenome:MGI:1921499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2400002D05Rik; 4933431K03Rik
    Summary
    Acts upstream of or within cellular response to leukemia inhibitory factor. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human LRRC2 (leucine rich repeat containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in heart adult (RPKM 15.3) and ovary adult (RPKM 1.0) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Lrrc2 in Genome Data Viewer
    Location:
    9 60.79 cM; 9 F2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110780613..110813134)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110951545..110984066)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 240 member A Neighboring gene CRISPRi-validated Tdgf1 proximal enhancer Neighboring gene cripto, EGF-CFC family member Neighboring gene predicted gene 10030 Neighboring gene receptor transporter protein 3 Neighboring gene lactotransferrin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (3) 

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028838.2NP_083114.2  leucine-rich repeat-containing protein 2

      See identical proteins and their annotated locations for NP_083114.2

      Status: VALIDATED

      Source sequence(s)
      AC118727, AK010252
      Consensus CDS
      CCDS23580.1
      UniProtKB/Swiss-Prot
      Q8VDB8, Q9CX04
      UniProtKB/TrEMBL
      A0A0R4J0F2
      Related
      ENSMUSP00000035076.5, ENSMUST00000035076.9
      Conserved Domains (2) summary
      COG4886
      Location:99368
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:123145
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      110780613..110813134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512364.5XP_006512427.1  leucine-rich repeat-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8VDB8, Q9CX04
      Conserved Domains (2) summary
      COG4886
      Location:107376
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:131153
      LRR_RI; leucine-rich repeat [structural motif]
    2. XM_006512365.5XP_006512428.1  leucine-rich repeat-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006512428.1

      UniProtKB/Swiss-Prot
      Q8VDB8, Q9CX04
      UniProtKB/TrEMBL
      A0A0R4J0F2
      Conserved Domains (2) summary
      COG4886
      Location:99368
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:123145
      LRR_RI; leucine-rich repeat [structural motif]