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    Lpp LIM domain containing preferred translocation partner in lipoma [ Mus musculus (house mouse) ]

    Gene ID: 210126, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lppprovided by MGI
    Official Full Name
    LIM domain containing preferred translocation partner in lipomaprovided by MGI
    Primary source
    MGI:MGI:2441849
    See related
    Ensembl:ENSMUSG00000033306 AllianceGenome:MGI:2441849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D630048H16; 9430020K16Rik; B130055L10Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be located in cytosol. Predicted to be active in focal adhesion and stress fiber. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and musculoskeletal system. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human LPP (LIM domain containing preferred translocation partner in lipoma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 60.6), subcutaneous fat pad adult (RPKM 8.5) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lpp in Genome Data Viewer
    Location:
    16 B1; 16 16.17 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (24212100..24811328)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (24393350..24992578)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40457 Neighboring gene predicted gene, 41434 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:24428914-24429115 Neighboring gene BMP2 inducible kinase pseudogene Neighboring gene predicted gene, 24440 Neighboring gene LIM domain containing preferred translocation partner in lipoma, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E7434 Neighboring gene STARR-seq mESC enhancer starr_40461 Neighboring gene STARR-seq mESC enhancer starr_40463 Neighboring gene mortality factor 4 like 1, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2458 Neighboring gene STARR-seq mESC enhancer starr_40465 Neighboring gene microRNA 28a Neighboring gene predicted gene, 22672 Neighboring gene predicted gene, 52245 Neighboring gene STARR-seq mESC enhancer starr_40468 Neighboring gene STARR-seq mESC enhancer starr_40471 Neighboring gene RIKEN cDNA A230028O05 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:25055618-25055819 Neighboring gene STARR-seq mESC enhancer starr_40472 Neighboring gene predicted gene, 52256

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts. Fedele M, et al. Oncogene, 1998 Jul 30. PMID 9696033
    2. Targeted disruption of the mouse Lipoma Preferred Partner gene. Vervenne HB, et al. Biochem Biophys Res Commun, 2009 Feb 6. PMID 19111675
    3. Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction. Yang W, et al. Cell Chem Biol, 2023 Oct 19. PMID 37442135
    4. The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation. Kiepas A, et al. J Biol Chem, 2020 Jul 31. PMID 32299913, Free PMC Article
    5. Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance. Leung CS, et al. J Clin Invest, 2018 Feb 1. PMID 29251630, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation.
      Title: The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation.
    2. cancer-associated fibroblasts regulate endothelial LPP via a calcium-dependent signaling pathway involving microfibrillar-associated protein 5 (MFAP5), focal adhesion kinase (FAK), ERK, and LPP
      Title: Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance.
    3. Inactivation of Rho kinase (ROK) with ROK inhibitors significantly inhibited LPP mRNA expression in TGF-beta1-treated SMPCs.
      Title: TGF-β1-induced LPP expression dependant on Rho kinase during differentiation and migration of bone marrow-derived smooth muscle progenitor cells.
    4. interaction between LPP and alpha-actinin, an actin cross-linking protein, is necessary for TGFbeta-induced migration and invasion of ErbB2-expressing breast cancer cells.
      Title: A complex containing LPP and α-actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells.
    5. Mice with a targeted disruption of the Lpp gene were generated, and the importance of Lpp for embryonic development and adult functions was analysed.
      Title: Targeted disruption of the mouse Lipoma Preferred Partner gene.
    6. expression of LPP in smooth muscle is mediated by an alternative promoter that is regulated by SRF/myocardin.
      Title: Smooth muscle expression of lipoma preferred partner is mediated by an alternative intronic promoter that is regulated by serum response factor/myocardin.
    7. LPP contains specific domains that enable its focal adhesion and nuclear targeting capacity [LIM-containing lipoma-preferred partner [LPP]
      Title: The focal adhesion and nuclear targeting capacity of the LIM-containing lipoma-preferred partner (LPP) protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lipoma-preferred partner homolog
    Names
    lipoma preferred partner

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145952.1 → NP_001139424.1  lipoma-preferred partner homolog isoform 1

      See identical proteins and their annotated locations for NP_001139424.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC135567, AK040643, AK050035, AK054550, AK085890, BF018106
      Consensus CDS
      CCDS28083.1
      UniProtKB/Swiss-Prot
      Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
      Related
      ENSMUSP00000078005.3, ENSMUST00000078988.10
      Conserved Domains (4) summary
      cd09350
      Location:417 → 470
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PRK14086
      Location:192 → 388
      dnaA; chromosomal replication initiator protein DnaA
      PRK14971
      Location:139 → 240
      PRK14971; DNA polymerase III subunit gamma/tau
      cl02475
      Location:537 → 602
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. NM_001145954.1 → NP_001139426.1  lipoma-preferred partner homolog isoform 2

      See identical proteins and their annotated locations for NP_001139426.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This results in a shorter isoform (2) with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC135567, AK029567, AK040643, AK050035, AK085890, BF018106
      Consensus CDS
      CCDS49807.1
      UniProtKB/Swiss-Prot
      Q8BFW7
      Related
      ENSMUSP00000110969.3, ENSMUST00000115314.4
      Conserved Domains (3) summary
      cd09350
      Location:292 → 345
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      cl02475
      Location:412 → 477
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
      cl08186
      Location:42 → 160
      DUF3251; Protein of unknown function (DUF3251)

    3. NM_178665.5 → NP_848780.3  lipoma-preferred partner homolog isoform 1

      See identical proteins and their annotated locations for NP_848780.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC135567, AK040643, AK050035, AK085890, BF018106, CJ166632
      Consensus CDS
      CCDS28083.1
      UniProtKB/Swiss-Prot
      Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
      Related
      ENSMUSP00000036304.7, ENSMUST00000038053.14
      Conserved Domains (4) summary
      cd09350
      Location:417 → 470
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PRK14086
      Location:192 → 388
      dnaA; chromosomal replication initiator protein DnaA
      PRK14971
      Location:139 → 240
      PRK14971; DNA polymerase III subunit gamma/tau
      cl02475
      Location:537 → 602
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      24212100..24811328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316922.3 → XP_017172411.1  lipoma-preferred partner homolog isoform X2

      Conserved Domains (4) summary
      cd09350
      Location:416 → 469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PRK14086
      Location:191 → 387
      dnaA; chromosomal replication initiator protein DnaA
      PRK14971
      Location:138 → 239
      PRK14971; DNA polymerase III subunit gamma/tau
      cl02475
      Location:536 → 601
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_030249029.1 → XP_030104889.1  lipoma-preferred partner homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
      Conserved Domains (4) summary
      cd09350
      Location:417 → 470
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PRK14086
      Location:192 → 388
      dnaA; chromosomal replication initiator protein DnaA
      PRK14971
      Location:139 → 240
      PRK14971; DNA polymerase III subunit gamma/tau
      cl02475
      Location:537 → 602
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_030249032.1 → XP_030104892.1  lipoma-preferred partner homolog isoform X2

      Conserved Domains (4) summary
      cd09350
      Location:416 → 469
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PRK14086
      Location:191 → 387
      dnaA; chromosomal replication initiator protein DnaA
      PRK14971
      Location:138 → 239
      PRK14971; DNA polymerase III subunit gamma/tau
      cl02475
      Location:536 → 601
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_006521957.5 → XP_006522020.1  lipoma-preferred partner homolog isoform X1

      See identical proteins and their annotated locations for XP_006522020.1

      UniProtKB/Swiss-Prot
      Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
      Conserved Domains (4) summary
      cd09350
      Location:417 → 470
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PRK14086
      Location:192 → 388
      dnaA; chromosomal replication initiator protein DnaA
      PRK14971
      Location:139 → 240
      PRK14971; DNA polymerase III subunit gamma/tau
      cl02475
      Location:537 → 602
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    5. XM_030249028.2 → XP_030104888.1  lipoma-preferred partner homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
      Conserved Domains (4) summary
      cd09350
      Location:417 → 470
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PRK14086
      Location:192 → 388
      dnaA; chromosomal replication initiator protein DnaA
      PRK14971
      Location:139 → 240
      PRK14971; DNA polymerase III subunit gamma/tau
      cl02475
      Location:537 → 602
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    6. XM_030249031.1 → XP_030104891.1  lipoma-preferred partner homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
      Conserved Domains (4) summary
      cd09350
      Location:417 → 470
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PRK14086
      Location:192 → 388
      dnaA; chromosomal replication initiator protein DnaA
      PRK14971
      Location:139 → 240
      PRK14971; DNA polymerase III subunit gamma/tau
      cl02475
      Location:537 → 602
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    7. XM_030249030.2 → XP_030104890.1  lipoma-preferred partner homolog isoform X1

      UniProtKB/Swiss-Prot
      Q5U407, Q8BFW7, Q8BHI1, Q8BKI0, Q8BKN2, Q8BLF4, Q8BLG3, Q8C101
      Conserved Domains (4) summary
      cd09350
      Location:417 → 470
      LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)
      PRK14086
      Location:192 → 388
      dnaA; chromosomal replication initiator protein DnaA
      PRK14971
      Location:139 → 240
      PRK14971; DNA polymerase III subunit gamma/tau
      cl02475
      Location:537 → 602
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFW7.1 GenPept UniProtKB/Swiss-Prot:Q8BFW7

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