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    Adamtsl4 ADAMTS-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 229595, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adamtsl4provided by MGI
    Official Full Name
    ADAMTS-like 4provided by MGI
    Primary source
    MGI:MGI:2389008
    See related
    Ensembl:ENSMUSG00000015850 AllianceGenome:MGI:2389008
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tsrc1; ADAMTSL-4
    Summary
    The protein encoded by this gene is a member of the ADAMTS superfamily of secreted proteins, which contain a metalloprotease domain at the N-terminus and a C-terminal ancillary domain. ADAMTS-like proteins lack protease activity and resemble the ancillary domain of ADAMTS proteins. ADAMTS-like proteins have been implicated in regulation of the extracellular matrix. The encoded protein contains 7 thrombospondin type 1 repeats, a conserved extracellular domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
    Expression
    Broad expression in lung adult (RPKM 18.4), bladder adult (RPKM 18.2) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adamtsl4 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95583511..95595232, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95676201..95687927, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10, pseudogene 1 Neighboring gene endosulfine alpha Neighboring gene CRISPRi-validated Mcl1 enhancer cluster Neighboring gene STARR-seq mESC enhancer starr_08389 Neighboring gene STARR-seq mESC enhancer starr_08391 Neighboring gene myeloid cell leukemia sequence 1 Neighboring gene STARR-seq mESC enhancer starr_08393 Neighboring gene STARR-seq mESC enhancer starr_08394 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:95511513-95511622 Neighboring gene microRNA 7014 Neighboring gene extracellular matrix protein 1 Neighboring gene threonyl-tRNA synthetase 2, mitochondrial (putative) Neighboring gene STARR-positive B cell enhancer ABC_E2087

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic and functional linkage between ADAMTS superfamily proteins and fibrillin-1: a novel mechanism influencing microfibril assembly and function. Hubmacher D, et al. Cell Mol Life Sci, 2011 Oct. PMID 21858451, Free PMC Article
    2. TSRC1, a widely expressed gene containing seven thrombospondin type I repeats. Buchner DA, et al. Gene, 2003 Mar 27. PMID 12706885
    3. Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation. Collin GB, et al. Hum Mol Genet, 2015 Dec 15. PMID 26405179, Free PMC Article
    4. O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Du J, et al. Dev Biol, 2010 Oct 1. PMID 20637190, Free PMC Article
    5. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the first ADAMTSL4 mouse model, tvrm267, bearing a nonsense mutation in Adamtsl4
      Title: Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation.
    2. O-fucose modification of thrombospondin type 1 repeats was essential for modulation of growth factor signaling during gastrulation.
      Title: O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28749

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within extracellular matrix organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pigment cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in interstitial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ADAMTS-like protein 4
    Names
    thrombospondin repeat containing 1
    thrombospondin repeat protein 1
    thrombospondin repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301705.1 → NP_001288634.1  ADAMTS-like protein 4 precursor

      See identical proteins and their annotated locations for NP_001288634.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC093317, AI595354, AY158701, BY196249, BY204619
      Consensus CDS
      CCDS17618.1
      UniProtKB/Swiss-Prot
      Q148X6, Q80T21
      Related
      ENSMUSP00000113424.2, ENSMUST00000117782.8
      Conserved Domains (5) summary
      smart00209
      Location:46 → 70
      TSP1; Thrombospondin type 1 repeats
      PHA03247
      Location:161 → 360
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:449 → 563
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:995 → 1024
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:691 → 747
      TSP1_ADAMTS; Thrombospondin type 1 domain

    2. NM_144899.3 → NP_659148.2  ADAMTS-like protein 4 precursor

      See identical proteins and their annotated locations for NP_659148.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC093317, AI595354, AY158701, BY204619
      Consensus CDS
      CCDS17618.1
      UniProtKB/Swiss-Prot
      Q148X6, Q80T21
      Related
      ENSMUSP00000015994.4, ENSMUST00000015994.4
      Conserved Domains (5) summary
      smart00209
      Location:46 → 70
      TSP1; Thrombospondin type 1 repeats
      PHA03247
      Location:161 → 360
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:449 → 563
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:995 → 1024
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:691 → 747
      TSP1_ADAMTS; Thrombospondin type 1 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95583511..95595232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163061.1 → XP_036018954.1  ADAMTS-like protein 4 isoform X2

      Conserved Domains (4) summary
      smart00209
      Location:46 → 70
      TSP1; Thrombospondin type 1 repeats
      PHA03247
      Location:170 → 360
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:449 → 563
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam19030
      Location:691 → 747
      TSP1_ADAMTS; Thrombospondin type 1 domain

    2. XM_036163059.1 → XP_036018952.1  ADAMTS-like protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q148X6, Q80T21
      Conserved Domains (5) summary
      smart00209
      Location:46 → 70
      TSP1; Thrombospondin type 1 repeats
      PHA03247
      Location:161 → 360
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:449 → 563
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:995 → 1024
      PLAC; PLAC (protease and lacunin) domain
      pfam19030
      Location:691 → 747
      TSP1_ADAMTS; Thrombospondin type 1 domain

    3. XM_036163062.1 → XP_036018955.1  ADAMTS-like protein 4 isoform X3

      Conserved Domains (4) summary
      smart00209
      Location:46 → 70
      TSP1; Thrombospondin type 1 repeats
      PHA03247
      Location:170 → 360
      PHA03247; large tegument protein UL36; Provisional
      pfam05986
      Location:449 → 563
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam19030
      Location:691 → 747
      TSP1_ADAMTS; Thrombospondin type 1 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80T21.1 GenPept UniProtKB/Swiss-Prot:Q80T21

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