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    Gpr52 G protein-coupled receptor 52 [ Mus musculus (house mouse) ]

    Gene ID: 620246, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr52provided by MGI
    Official Full Name
    G protein-coupled receptor 52provided by MGI
    Primary source
    MGI:MGI:3643278
    See related
    Ensembl:ENSMUSG00000118401 AllianceGenome:MGI:3643278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG620246
    Summary
    Predicted to enable G protein-coupled photoreceptor activity. Involved in locomotory behavior. Predicted to be active in plasma membrane. Orthologous to human GPR52 (G protein-coupled receptor 52). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 1.5), frontal lobe adult (RPKM 1.4) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr52 in Genome Data Viewer
    Location:
    1 H2.1; 1 69.75 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (160402287..160407274, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (160574717..160579704, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933417C20 gene Neighboring gene STARR-seq mESC enhancer starr_02796 Neighboring gene STARR-seq mESC enhancer starr_02797 Neighboring gene STARR-seq mESC enhancer starr_02798 Neighboring gene STARR-positive B cell enhancer ABC_E9188 Neighboring gene STARR-positive B cell enhancer ABC_E5830 Neighboring gene STARR-positive B cell enhancer ABC_E5831 Neighboring gene RAB GTPase activating protein 1-like Neighboring gene STARR-seq mESC enhancer starr_02799 Neighboring gene STARR-seq mESC enhancer starr_02800 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:162237326-162237707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:162239161-162239370 Neighboring gene microRNA 1927 Neighboring gene STARR-seq mESC enhancer starr_02802 Neighboring gene STARR-seq mESC enhancer starr_02803 Neighboring gene STARR-positive B cell enhancer ABC_E5832 Neighboring gene STARR-seq mESC enhancer starr_02805 Neighboring gene STARR-seq mESC enhancer starr_02807 Neighboring gene predicted gene, 23528 Neighboring gene STARR-seq mESC enhancer starr_02810 Neighboring gene STARR-positive B cell enhancer mm9_chr1:162722911-162723212 Neighboring gene STARR-positive B cell enhancer ABC_E7764 Neighboring gene predicted gene, 37083

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Orphan receptor-GPR52 inverse agonist efficacy in ameliorating chronic stress-related deficits in reward motivation and phasic accumbal dopamine activity in mice. Zhang C, et al. Transl Psychiatry, 2024 Sep 7. PMID 39242529, Free PMC Article
    2. GPR52 regulates cAMP in T cells but is dispensable for encephalitogenic responses. Krieg PF, et al. Front Immunol, 2022. PMID 36761164, Free PMC Article
    3. GPR52 accelerates fatty acid biosynthesis in a ligand-dependent manner in hepatocytes and in response to excessive fat intake in mice. Wada M, et al. iScience, 2021 Apr 23. PMID 33796846, Free PMC Article
    4. Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes. Song H, et al. Brain, 2018 Jun 1. PMID 29608652, Free PMC Article
    5. β-Arrestin-2-Dependent Mechanism of GPR52 Signaling in Frontal Cortical Neurons. Hatzipantelis CJ, et al. ACS Chem Neurosci, 2020 Jul 15. PMID 32519845

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Orphan receptor-GPR52 inverse agonist efficacy in ameliorating chronic stress-related deficits in reward motivation and phasic accumbal dopamine activity in mice.
      Title: Orphan receptor-GPR52 inverse agonist efficacy in ameliorating chronic stress-related deficits in reward motivation and phasic accumbal dopamine activity in mice.
    2. beta-Arrestin-2-Dependent Mechanism of GPR52 Signaling in Frontal Cortical Neurons.
      Title: β-Arrestin-2-Dependent Mechanism of GPR52 Signaling in Frontal Cortical Neurons.
    3. This study demonstrated that the Knocking-out Gpr52 significantly reduces mutant HTT levels in the striatum and rescues Huntington's disease-associated behavioural phenotypes in a knock-in Huntington's disease mouse model expressing endogenous mutant Htt.
      Title: Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes.
    4. GPR52 has the potential of being a therapeutic psychiatric receptor.
      Title: Anatomical transcriptome of G protein-coupled receptors leads to the identification of a novel therapeutic candidate GPR52 for psychiatric disorders.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled photoreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to light stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 52
    Names
    probable G-protein coupled receptor 52

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146330.2 → NP_001139802.1  G-protein coupled receptor 52

      See identical proteins and their annotated locations for NP_001139802.1

      Status: VALIDATED

      Source sequence(s)
      AC117787
      Consensus CDS
      CCDS87900.1
      UniProtKB/Swiss-Prot
      P0C5J4
      Related
      ENSMUSP00000158769.2, ENSMUST00000238289.2
      Conserved Domains (1) summary
      cd00637
      Location:43 → 321
      7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001368668.1 → NP_001355597.1  G-protein coupled receptor 52

      Status: VALIDATED

      Source sequence(s)
      AC117787
      Consensus CDS
      CCDS87900.1
      UniProtKB/Swiss-Prot
      P0C5J4
      Conserved Domains (1) summary
      cd00637
      Location:43 → 321
      7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      160402287..160407274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C5J4.1 GenPept UniProtKB/Swiss-Prot:P0C5J4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials