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    Ssh2 slingshot protein phosphatase 2 [ Mus musculus (house mouse) ]

    Gene ID: 237860, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ssh2provided by MGI
    Official Full Name
    slingshot protein phosphatase 2provided by MGI
    Primary source
    MGI:MGI:2679255
    See related
    Ensembl:ENSMUSG00000037926 AllianceGenome:MGI:2679255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SSH-2; SSH-2L; mSSH-2L
    Summary
    Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Predicted to be involved in several processes, including negative regulation of actin filament polymerization; positive regulation of cell migration; and protein dephosphorylation. Predicted to be located in acrosomal vesicle; cytoskeleton; and focal adhesion. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and neural retinal epithelium. Orthologous to human SSH2 (slingshot protein phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 9.0), heart adult (RPKM 4.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ssh2 in Genome Data Viewer
    Location:
    11 B5; 11 46.36 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77107020..77351046)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77216157..77460220)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 5 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30052 Neighboring gene upstream transcription factor 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8428 Neighboring gene STARR-positive B cell enhancer ABC_E7022 Neighboring gene STARR-positive B cell enhancer ABC_E3978 Neighboring gene predicted gene, 24989 Neighboring gene heat shock protein 1, alpha pseudogene Neighboring gene STARR-seq mESC enhancer starr_30053 Neighboring gene VISTA enhancer mm146 Neighboring gene 60S ribosomal protein L35-like Neighboring gene STARR-positive B cell enhancer ABC_E5248 Neighboring gene STARR-seq mESC enhancer starr_30055 Neighboring gene microRNA mir-12181 Neighboring gene ankyrin repeat domain 13b Neighboring gene coronin 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis. Tang W, et al. Dev Cell, 2011 Dec 13. PMID 22172670, Free PMC Article
    2. Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for mouse development. Kousaka K, et al. Genesis, 2008 May. PMID 18442045
    3. Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. Ohta Y, et al. Genes Cells, 2003 Oct. PMID 14531860
    4. Coordination of Cellular Dynamics Contributes to Tooth Epithelium Deformations. Morita R, et al. PLoS One, 2016. PMID 27588418, Free PMC Article
    5. Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A PLCbeta/PI3Kgamma-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis.
      Title: A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase Slingshot homolog 2
    Names
    SSH-like protein 2
    slingshot 2L
    slingshot homolog 2
    slingshot-like 2
    NP_001278119.1
    NP_808378.2
    XP_006533290.1
    XP_006533291.1
    XP_006533292.1
    XP_030101826.1
    XP_036012553.1
    XP_036012554.1
    XP_036012555.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291190.1 → NP_001278119.1  protein phosphatase Slingshot homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_001278119.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, uses an alternate start codon, and uses an alternate splice site in the central coding region, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB099288, AK158449, AL607072
      Consensus CDS
      CCDS70248.1
      UniProtKB/TrEMBL
      A0A0R4J2A0
      Related
      ENSMUSP00000137933.2, ENSMUST00000181283.3
      Conserved Domains (3) summary
      cd11652
      Location:10 → 242
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:314 → 449
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:257 → 308
      DEK_C; DEK C terminal domain

    2. NM_177710.4 → NP_808378.2  protein phosphatase Slingshot homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_808378.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AB099288, AL607072, BC141393
      Consensus CDS
      CCDS25076.1
      UniProtKB/Swiss-Prot
      B9EJ94, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q5SW75, Q69ZC3, Q76I78
      Related
      ENSMUSP00000042625.6, ENSMUST00000037912.12
      Conserved Domains (3) summary
      cd11652
      Location:3 → 236
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd00127
      Location:308 → 443
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      pfam08766
      Location:251 → 302
      DEK_C; DEK C terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      77107020..77351046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533227.5 → XP_006533290.1  protein phosphatase Slingshot homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5SW75
      Conserved Domains (3) summary
      cd11652
      Location:40 → 263
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd14569
      Location:332 → 475
      DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
      pfam08766
      Location:277 → 329
      DEK_C; DEK C terminal domain

    2. XM_036156662.1 → XP_036012555.1  protein phosphatase Slingshot homolog 2 isoform X7

      Conserved Domains (3) summary
      cd11652
      Location:3 → 191
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd14569
      Location:260 → 403
      DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
      pfam08766
      Location:205 → 257
      DEK_C; DEK C terminal domain

    3. XM_030245966.2 → XP_030101826.1  protein phosphatase Slingshot homolog 2 isoform X4

      Conserved Domains (3) summary
      cd11652
      Location:3 → 235
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd14569
      Location:304 → 447
      DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
      pfam08766
      Location:249 → 301
      DEK_C; DEK C terminal domain

    4. XM_006533228.5 → XP_006533291.1  protein phosphatase Slingshot homolog 2 isoform X2

      Conserved Domains (3) summary
      cd11652
      Location:40 → 262
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd14569
      Location:331 → 474
      DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
      pfam08766
      Location:276 → 328
      DEK_C; DEK C terminal domain

    5. XM_036156660.1 → XP_036012553.1  protein phosphatase Slingshot homolog 2 isoform X5

      Conserved Domains (3) summary
      cd11652
      Location:40 → 218
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd14569
      Location:287 → 430
      DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
      pfam08766
      Location:232 → 284
      DEK_C; DEK C terminal domain

    6. XM_006533229.5 → XP_006533292.1  protein phosphatase Slingshot homolog 2 isoform X3

      See identical proteins and their annotated locations for XP_006533292.1

      UniProtKB/Swiss-Prot
      Q5SW75
      Conserved Domains (3) summary
      cd11652
      Location:10 → 243
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd14569
      Location:312 → 455
      DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
      pfam08766
      Location:257 → 309
      DEK_C; DEK C terminal domain

    7. XM_036156661.1 → XP_036012554.1  protein phosphatase Slingshot homolog 2 isoform X6

      Conserved Domains (3) summary
      cd11652
      Location:10 → 198
      SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
      cd14569
      Location:267 → 410
      DSP_slingshot_2; dual specificity phosphatase domain of slingshot homolog 2
      pfam08766
      Location:212 → 264
      DEK_C; DEK C terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SW75.2 GenPept UniProtKB/Swiss-Prot:Q5SW75

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