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    Rel reticuloendotheliosis oncogene [ Mus musculus (house mouse) ]

    Gene ID: 19696, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Relprovided by MGI
    Official Full Name
    reticuloendotheliosis oncogeneprovided by MGI
    Primary source
    MGI:MGI:97897
    See related
    Ensembl:ENSMUSG00000020275 AllianceGenome:MGI:97897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    c-Rel
    Summary
    Enables DNA-binding transcription factor activity. Acts upstream of or within positive regulation of DNA-templated transcription and positive regulation of interleukin-12 production. Located in cytoplasm and nucleus. Is expressed in central nervous system; eye; genitourinary system; heart; and spleen primordium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human REL (REL proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 6.1), thymus adult (RPKM 3.0) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rel in Genome Data Viewer
    Location:
    11 A3.2; 11 14.36 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23686847..23720969, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23736847..23770969, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SANT and BTB domain regulator of CSR Neighboring gene peroxisomal biogenesis factor 13 Neighboring gene pseudouridylate synthase 10 Neighboring gene STARR-seq mESC enhancer starr_28923 Neighboring gene STARR-seq mESC enhancer starr_28924 Neighboring gene predicted gene, 39612 Neighboring gene STARR-seq mESC enhancer starr_28925 Neighboring gene poly(A) polymerase gamma Neighboring gene STARR-positive B cell enhancer mm9_chr11:23795118-23795419 Neighboring gene predicted gene 12061

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. c-Rel is a target of pentoxifylline-mediated inhibition of T lymphocyte activation. Wang W, et al. Immunity, 1997 Feb. PMID 9047238
    2. A Regulatory Circuit Controlling the Dynamics of NFκB cRel Transitions B Cells from Proliferation to Plasma Cell Differentiation. Roy K, et al. Immunity, 2019 Mar 19. PMID 30850343, Free PMC Article
    3. Developmental expression of the mouse c-rel proto-oncogene in hematopoietic organs. Carrasco D, et al. Development, 1994 Oct. PMID 7607087
    4. Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors. O'Riordan KJ, et al. J Neurosci, 2006 May 3. PMID 16672661, Free PMC Article
    5. Mild Inflammatory Profile without Gliosis in the c-Rel Deficient Mouse Modeling a Late-Onset Parkinsonism. Porrini V, et al. Front Aging Neurosci, 2017. PMID 28769786, Free PMC Article

    See all (265) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Direct observation correlates NFkappaB cRel in B cells with activating and terminating their proliferative program.
      Title: Direct observation correlates NFκB cRel in B cells with activating and terminating their proliferative program.
    2. NF-kappaB subunits RelA and c-Rel selectively control CD4+ T cell function in multiple sclerosis and cancer.
      Title: NF-κB subunits RelA and c-Rel selectively control CD4+ T cell function in multiple sclerosis and cancer.
    3. Co-imaging of RelA and c-Rel reveals features of NF-kappaB signaling for ligand discrimination.
      Title: Co-imaging of RelA and c-Rel reveals features of NF-κB signaling for ligand discrimination.
    4. c-Rel-dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis.
      Title: c-Rel-dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis.
    5. The c-Rel transcription factor limits early interferon and neuroinflammatory responses to prevent herpes simplex encephalitis onset in mice.
      Title: The c-Rel transcription factor limits early interferon and neuroinflammatory responses to prevent herpes simplex encephalitis onset in mice.
    6. The NF-kappaB Transcription Factor c-Rel Modulates Group 2 Innate Lymphoid Cell Effector Functions and Drives Allergic Airway Inflammation.
      Title: The NF-κB Transcription Factor c-Rel Modulates Group 2 Innate Lymphoid Cell Effector Functions and Drives Allergic Airway Inflammation.
    7. Integrative analysis suggests cell type-specific decoding of NF-kappaB dynamics.
      Title: Integrative analysis suggests cell type-specific decoding of NF-κB dynamics.
    8. c-Rel employs multiple mechanisms to promote the thymic development and peripheral function of regulatory T cells in mice.
      Title: c-Rel employs multiple mechanisms to promote the thymic development and peripheral function of regulatory T cells in mice.
    9. NF-kappaB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells.
      Title: NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells.
    10. Extracellular Release of Antigen by Dendritic Cell Regurgitation Promotes B Cell Activation through NF-kappaB/cRel.
      Title: Extracellular Release of Antigen by Dendritic Cell Regurgitation Promotes B Cell Activation through NF-κB/cRel.
    Submit: New GeneRIF Correction See all GeneRIFs (87)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in non-canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cytokine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    proto-oncogene c-Rel
    Names
    C-Rel proto-oncogene protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009044.3 → NP_033070.2  proto-oncogene c-Rel

      See identical proteins and their annotated locations for NP_033070.2

      Status: VALIDATED

      Source sequence(s)
      AL805916
      Consensus CDS
      CCDS24480.1
      UniProtKB/Swiss-Prot
      P15307
      UniProtKB/TrEMBL
      A4QPD3
      Related
      ENSMUSP00000099928.4, ENSMUST00000102864.5
      Conserved Domains (2) summary
      cd07933
      Location:8 → 179
      RHD-n_c-Rel; N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel
      pfam16179
      Location:187 → 282
      RHD_dimer; Rel homology dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      23686847..23720969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15307.2 GenPept UniProtKB/Swiss-Prot:P15307

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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