Mapk15 mitogen-activated protein kinase 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mapk15provided by MGI
Official Full Name: mitogen-activated protein kinase 15provided by MGI
Primary source: MGI:MGI:2652894
See related: Ensembl:ENSMUSG00000063704 AllianceGenome:MGI:2652894
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ERK-8
Summary: Predicted to enable MAP kinase activity and chromatin binding activity. Involved in positive regulation of metaphase/anaphase transition of meiosis I; positive regulation of spindle assembly; and regulation of cilium assembly. Located in meiotic spindle. Is expressed in several structures, including brain; genitourinary system; limb; nose; and viscerocranium. Orthologous to human MAPK15 (mitogen-activated protein kinase 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 48.8), lung adult (RPKM 26.9) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 35.2 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (75865581..75871002)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (75993732..75999153)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Taken together, our results suggest that ERK8 plays an important role in spindle organization during mouse oocyte meiotic maturation and early embryo cleavage.
Title: The distribution and possible role of ERK8 in mouse oocyte meiotic maturation and early embryo cleavage.
a novel function for ERK8 as a bona fide ERRalpha corepressor, involved in control of its cellular localization by nuclear exclusion, and suggest a key role for this MAP kinase in the regulation of the biological activities of this nuclear receptor.
Title: Extracellular signal-regulated kinase 8 (ERK8) controls estrogen-related receptor α (ERRα) cellular localization and inhibits its transcriptional activity.
Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer
Title: Extracellular signal-regulated kinase 8-mediated c-Jun phosphorylation increases tumorigenesis of human colon cancer.
Erk8 has a role as a novel effector of RET/PTC3 and, therefore, RET biological functions
Title: Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	ISO Inferred from Sequence Orthology more info
enables MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in dopamine uptake	ISO Inferred from Sequence Orthology more info
involved_in dopamine uptake	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum organization	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of metaphase/anaphase transition of meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of telomere capping	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to ciliary transition zone	IEA Inferred from Electronic Annotation more info
involved_in protein localization to ciliary transition zone	ISO Inferred from Sequence Orthology more info
involved_in regulation of COPII vesicle coating	ISO Inferred from Sequence Orthology more info
involved_in regulation of COPII vesicle coating	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estradiol	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in autophagosome	ISS Inferred from Sequence or Structural Similarity more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in meiotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitogen-activated protein kinase 15

Names: ERK-7; MAP kinase 15; MAPK 15; extracellular signal-regulated kinase 7; extracellular signal-regulated kinase 8

NP_001403335.1

EC 2.7.11.24

NP_001403336.1

EC 2.7.11.24

NP_001403337.1

EC 2.7.11.24

NP_808590.1

EC 2.7.11.24

XP_006521162.1

EC 2.7.11.24

XP_006521163.1

EC 2.7.11.24

XP_006521164.1

EC 2.7.11.24

XP_006521165.1

EC 2.7.11.24

XP_006521166.1

EC 2.7.11.24

XP_006521167.1

EC 2.7.11.24

XP_006521169.1

EC 2.7.11.24

XP_011243980.1

EC 2.7.11.24

XP_011243981.1

EC 2.7.11.24

XP_017172159.1

EC 2.7.11.24

XP_017172160.1

EC 2.7.11.24

XP_030104475.1

EC 2.7.11.24

XP_030104476.1

EC 2.7.11.24

XP_036015365.1

EC 2.7.11.24

XP_036015366.1

EC 2.7.11.24

XP_036015367.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416406.1 → NP_001403335.1 mitogen-activated protein kinase 15 isoform 2

Status: VALIDATED

Source sequence(s)

AC116487
NM_001416407.1 → NP_001403336.1 mitogen-activated protein kinase 15 isoform 2

Status: VALIDATED

Source sequence(s)

AC116487
NM_001416408.1 → NP_001403337.1 mitogen-activated protein kinase 15 isoform 3

Status: VALIDATED

Source sequence(s)

AC116487
NM_177922.3 → NP_808590.1 mitogen-activated protein kinase 15 isoform 1

See identical proteins and their annotated locations for NP_808590.1

Status: VALIDATED

Source sequence(s)

AC116487

Consensus CDS

CCDS27558.1

UniProtKB/Swiss-Prot

Q80Y86

Related

ENSMUSP00000087098.5, ENSMUST00000089669.6

Conserved Domains (2) summary

smart00220
Location:14 → 305

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07852
Location:6 → 344

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

75865581..75871002

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521104.4 → XP_006521167.1 mitogen-activated protein kinase 15 isoform X6

See identical proteins and their annotated locations for XP_006521167.1

Conserved Domains (1) summary

cd07852
Location:6 → 374

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
XM_006521103.3 → XP_006521166.1 mitogen-activated protein kinase 15 isoform X6

See identical proteins and their annotated locations for XP_006521166.1

Conserved Domains (1) summary

cd07852
Location:6 → 374

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
XM_006521106.3 → XP_006521169.1 mitogen-activated protein kinase 15 isoform X8

Conserved Domains (1) summary

cd07852
Location:6 → 344

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
XM_006521099.3 → XP_006521162.1 mitogen-activated protein kinase 15 isoform X1

Conserved Domains (1) summary

cd07852
Location:6 → 374

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
XM_006521101.3 → XP_006521164.1 mitogen-activated protein kinase 15 isoform X3

Conserved Domains (1) summary

cd07852
Location:6 → 364

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
XM_011245678.4 → XP_011243980.1 mitogen-activated protein kinase 15 isoform X12
XM_011245679.4 → XP_011243981.1 mitogen-activated protein kinase 15 isoform X13
XM_006521100.3 → XP_006521163.1 mitogen-activated protein kinase 15 isoform X2

Conserved Domains (1) summary

cd07852
Location:6 → 374

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
XM_006521102.3 → XP_006521165.1 mitogen-activated protein kinase 15 isoform X4

Conserved Domains (1) summary

cd07852
Location:6 → 344

STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
XM_030248615.2 → XP_030104475.1 mitogen-activated protein kinase 15 isoform X7

Conserved Domains (1) summary

cl21453
Location:58 → 237

PKc_like; Protein Kinases, catalytic domain
XM_030248616.2 → XP_030104476.1 mitogen-activated protein kinase 15 isoform X7

Conserved Domains (1) summary

cl21453
Location:58 → 237

PKc_like; Protein Kinases, catalytic domain
XM_036159473.1 → XP_036015366.1 mitogen-activated protein kinase 15 isoform X9

Conserved Domains (1) summary

cl21453
Location:58 → 207

PKc_like; Protein Kinases, catalytic domain
XM_017316671.3 → XP_017172160.1 mitogen-activated protein kinase 15 isoform X14

Conserved Domains (1) summary

cl21453
Location:58 → 207

PKc_like; Protein Kinases, catalytic domain
XM_017316670.3 → XP_017172159.1 mitogen-activated protein kinase 15 isoform X9

Conserved Domains (1) summary

cl21453
Location:58 → 207

PKc_like; Protein Kinases, catalytic domain
XM_036159474.1 → XP_036015367.1 mitogen-activated protein kinase 15 isoform X10

Conserved Domains (1) summary

cl21453
Location:58 → 207

PKc_like; Protein Kinases, catalytic domain
XM_036159472.1 → XP_036015365.1 mitogen-activated protein kinase 15 isoform X9

Conserved Domains (1) summary

cl21453
Location:58 → 207

PKc_like; Protein Kinases, catalytic domain